2,2-Dimethylpropylmagnesium chloride solution
2,2-Dimethylpropylmagnesium chloride solution (CAS: 13132-23-5) is an organometallic reagent, commonly supplied as a 1.0 M solution in diethyl ether. With a molecular weight of 130.90 g/mol, this Grignard reagent serves as a valuable nucleophile in organic synthesis. It is typically employed for introducing the neopentyl group in the preparation of various complex organic molecules and pharmaceutical intermediates, necessitating careful handling due to its reactivity.
- IUPAC
- Neopentylmagnesium chloride
- Synonyms
- (CH₃)₃CCH₂MgClNeopentylmagnesium chloride
Neopentyl Group Introduction
Serves as a key reagent for the alkylation of electrophiles, enabling the efficient introduction of the bulky neopentyl group into organic molecules. This is crucial in the synthesis of complex organic structures and fine chemicals.
Grignard Reactions
As a Grignard reagent, it participates in a wide range of carbon-carbon bond-forming reactions, including additions to carbonyl compounds and reactions with epoxides. This versatility makes it indispensable in synthetic organic chemistry.
Pharmaceutical Intermediate Synthesis
Utilised in the multi-step synthesis of active pharmaceutical ingredients (APIs) and their precursors. Its specific reactivity allows for controlled functionalisation in complex synthetic pathways.
Organometallic Chemistry Research
Employed in academic and industrial research settings for exploring new synthetic methodologies and developing novel organometallic compounds. Its defined structure and reactivity are beneficial for mechanistic studies.
| Molecular weight | 130.90 |
|---|---|
| Linear formula | (CH3)3CCH2MgCl |
| Density | 0.771 g/mL at 25 °C |
| Concentration | 1.0 M in diethyl ether |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P422
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14/15-19-34-37 |
| Safety statements (S) | 16-26-36/37/39-43-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2-Dimethylpropylmagnesium chloride solution used for?
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2,2-Dimethylpropylmagnesium chloride solution is primarily used as a nucleophile for introducing the neopentyl group into organic molecules, finding applications in general organic synthesis, the preparation of pharmaceutical intermediates, and organometallic research.
What is the CAS number and formula for 2,2-Dimethylpropylmagnesium chloride solution?
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The CAS number is 13132-23-5 and the linear formula is (CH₃)₃CCH₂MgCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 1.0 M solution in diethyl ether. We do not represent this product as USP, BP, or EP grade; it is intended for research and technical use.
How should 2,2-Dimethylpropylmagnesium chloride solution be handled and stored?
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This compound is highly reactive, flammable, and reacts violently with water. It is corrosive and can cause severe skin burns and eye damage, and may cause respiratory irritation. Store under an inert atmosphere at 2-8°C, away from ignition sources and incompatible materials like water and acids.
How is 2,2-Dimethylpropylmagnesium chloride solution packed, shipped, and exported?
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As a specialist global supplier, TSS ensures appropriate packaging and adherence to all regulations for the safe packing, shipping, and export of reactive chemicals like 2,2-Dimethylpropylmagnesium chloride solution.
How can I request a quote or sample?
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To request a quote or sample, please visit our website or contact our sales team directly with your requirements, including the product name, CAS number, and quantity.
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