2,6-Lutidine
2,6-Lutidine (CAS: 108-48-5), also known as 2,6-dimethylpyridine, is an organic compound with the molecular formula C7H9N. This heterocyclic amine is a colourless liquid with a characteristic pyridine odour. It is widely employed as a non-nucleophilic base and a catalyst in various organic syntheses, particularly in reactions requiring a sterically hindered base to prevent side reactions. Its applications span pharmaceutical development and fine chemical manufacturing.
- IUPAC
- 2,6-Dimethylpyridine
- Synonyms
- 2,6-DimethylpyridinePyridine, 2,6-dimethyl-
Non-Nucleophilic Base in Organic Synthesis
2,6-Lutidine serves as an effective non-nucleophilic base, ideal for deprotonation reactions where nucleophilic attack by the base would be detrimental. Its steric hindrance around the nitrogen atom minimises unwanted side reactions, making it a preferred choice for sensitive transformations.
Catalyst in Chemical Reactions
This compound acts as a catalyst in various organic transformations. It can facilitate reactions such as acylation and silylation by promoting the formation of reactive intermediates or neutralising acidic byproducts.
Building Block for Complex Molecules
As a substituted pyridine, 2,6-Lutidine is a valuable building block in the synthesis of more complex heterocyclic compounds. It is frequently used in the development of pharmaceutical intermediates and agrochemicals.
| Molecular weight | 107.15 |
|---|---|
| Empirical formula | C7H9N |
| Assay | ≥96.0% (GC) |
| Boiling point | 143-145 °C(lit.) |
| Density | 0.92 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.497(lit.)n20/D 1.498 |
| Melting point | −6 °C(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 37 °C / 98.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Purified By | redistillation |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Lutidine used for?
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2,6-Lutidine is primarily used as a non-nucleophilic base and a catalyst in organic synthesis. It is also employed as a building block for the synthesis of more complex organic molecules, including pharmaceutical intermediates.
What is the CAS number and formula for 2,6-Lutidine?
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The CAS number for 2,6-Lutidine is 108-48-5, and its empirical formula is C7H9N.
What grade and purity does Tech Serve Solutions supply for 2,6-Lutidine?
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Tech Serve Solutions supplies 2,6-Lutidine purified by redistillation with an assay of ≥96.0% (GC). We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling 2,6-Lutidine?
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2,6-Lutidine is a flammable liquid (H226) and is harmful if swallowed (H302). It can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, should be used. Handle in a well-ventilated area.
How is 2,6-Lutidine packed, shipped, and exported?
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2,6-Lutidine is available for export globally by Tech Serve Solutions. Packaging adheres to international shipping regulations for hazardous materials.
How can I request a quote or sample for 2,6-Lutidine?
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To request a quote or sample of 2,6-Lutidine, please contact the Tech Serve Solutions sales team through our website or by phone.
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