2,2,3,3-Tetramethyl-4,7,10,13,16-pentaoxa-3-silanonadec-18-yne
2,2,3,3-Tetramethyl-4,7,10,13,16-pentaoxa-3-silanonadec-18-yne (CAS: 203642-77-7) is a silicon-containing PEG-alkyne with the molecular formula C17H34O5Si and a molecular weight of 346.53 g/mol. This compound serves as a valuable protected PEG-alkyne building block. Its structure is ideal for introducing polyethylene glycol chains into molecules through robust click chemistry reactions or palladium-catalyzed coupling.
- Synonyms
- 3-Tetramethyl-4,7,10,13,16-pentaoxa-3-silanonadec-18-yneC17H34O5Si
Chemical Synthesis
Utilise this protected PEG-alkyne as a versatile building block in complex organic synthesis. Its alkyne functionality is ready for click chemistry or palladium-catalyzed coupling, allowing for the precise incorporation of PEG chains.
Chemical Biology
Employ in chemical biology for the modification of biomolecules or the creation of bioconjugates. The PEG chain can enhance solubility and reduce immunogenicity of labelled molecules.
Conjugation Chemistry
This compound is specifically designed for conjugation reactions, particularly Cu-catalyzed azide-alkyne cycloadditions (CuAAC) and palladium-catalyzed coupling. Its protected alkyne moiety ensures controlled reactivity.
Functionalized Alkynes
A key reagent in the synthesis of functionalized alkynes, enabling the introduction of PEG segments into various molecular scaffolds for diverse research applications.
| Molecular weight | 346.53 |
|---|---|
| Empirical formula | C17H34O5Si |
| Assay | 97% |
| Density | 0.980 g/mL at 25 °C |
| Refractive index | n20/D 1.451 |
| Application | Protected PEG-alkyne for Cu catalyzed azide-alkyne cycloadditions or palladium catalyzed coupling reactions. |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
Precautionary statements
- P301IF SWALLOWED
| Flash point | >110 °C / >230 °F |
|---|---|
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-38 |
| Safety statements (S) | 45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2,3,3-Tetramethyl-4,7,10,13,16-pentaoxa-3-silanonadec-18-yne used for?
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It is used as a protected PEG-alkyne for Cu-catalyzed azide-alkyne cycloadditions or palladium-catalyzed coupling reactions, serving as a versatile building block in chemical synthesis and chemical biology for bioconjugation.
What are the CAS number and formula for this compound?
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The CAS number is 203642-77-7 and the empirical formula is C17H34O5Si.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of 97%. This is a technical/research grade material and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2,2,3,3-Tetramethyl-4,7,10,13,16-pentaoxa-3-silanonadec-18-yne be handled?
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This compound is classified as dangerous. It carries signal word 'Danger' with hazard statements H301 (Toxic if swallowed) and H315 (Causes skin irritation). Handle with appropriate personal protective equipment in a well-ventilated area. Follow precautionary statement P301 + P310 (IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician).
Is this compound shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, including this compound.
How can I request a sample or quote?
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Please contact our sales team through the website or by phone to request a sample or a quotation for 2,2,3,3-Tetramethyl-4,7,10,13,16-pentaoxa-3-silanonadec-18-yne.
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