(1S,2R)-(−)-cis-1-Amino-2-indanol
(1S,2R)-(−)-cis-1-Amino-2-indanol (CAS: 126456-43-7) is a chiral organic compound with the molecular formula C9H11NO and a molecular weight of 149.19 g/mol. This amino alcohol serves as a valuable chiral building block and auxiliary in asymmetric synthesis. It is primarily utilised in organic synthesis to create enantiomerically pure compounds, particularly in the pharmaceutical and fine chemical industries, where stereochemistry is critical for activity.
- IUPAC
- (1S,2R)-(−)-cis-1-Amino-2-hydroxyindane
- Synonyms
- (1S,2R)-(−)-cis-1-Amino-2-hydroxyindane
Chiral Auxiliary in Asymmetric Synthesis
This compound is widely employed as a chiral auxiliary to induce stereoselectivity in various organic reactions. Its rigid structure and functional groups enable it to control the stereochemical outcome of reactions, leading to the formation of enantiomerically enriched products.
Building Block for Chiral Ligands
The molecule can be incorporated into the synthesis of chiral ligands used in asymmetric catalysis. These ligands are crucial for transition metal-catalyzed reactions, facilitating enantioselective transformations in complex molecule synthesis.
Intermediate in Pharmaceutical Synthesis
As a chiral intermediate, (1S,2R)-(−)-cis-1-Amino-2-indanol is used in the multi-step synthesis of pharmacologically active compounds. Its defined stereochemistry is essential for the biological activity and efficacy of drug candidates.
| Molecular weight | 149.19 |
|---|---|
| Empirical formula | C9H11NO |
| Assay | ≥98.0% (sum of enantiomers, GC) |
| Optical activity | [α]20/D −64±5°, c = 0.2% in chloroform |
| Optical purity | ee: 99% (GLC) |
| Melting point | 118-121 °C(lit.)118-122 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1S,2R)-(−)-cis-1-Amino-2-indanol used for?
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This compound is primarily used as a chiral auxiliary and building block in asymmetric synthesis, particularly for creating enantiomerically pure intermediates for pharmaceuticals and fine chemicals.
What are the CAS number and formula for (1S,2R)-(−)-cis-1-Amino-2-indanol?
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The CAS number is 126456-43-7, and the empirical formula is C9H11NO (Hill Notation).
What grade and purity does Tech Serve Solutions supply for (1S,2R)-(−)-cis-1-Amino-2-indanol?
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Tech Serve Solutions supplies this compound with an assay of ≥98.0% (sum of enantiomers, GC) and an optical purity of ee: 99% (GLC). We do not represent this product as USP, BP, or EP grade.
How should (1S,2R)-(−)-cis-1-Amino-2-indanol be handled?
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It is classified as a Warning under GHS, with hazards H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure good ventilation and avoid breathing dust.
Is (1S,2R)-(−)-cis-1-Amino-2-indanol a controlled substance?
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The provided data does not indicate that (1S,2R)-(−)-cis-1-Amino-2-indanol is a controlled substance.
How is this chemical packed and shipped by TSS?
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Tech Serve Solutions exports fine chemicals globally. Specific packing and shipping details are confirmed upon order based on quantity and destination, adhering to all relevant transport regulations.
How can I request a sample or quote for (1S,2R)-(−)-cis-1-Amino-2-indanol?
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To request a sample or quote, please visit the product page on the Tech Serve Solutions website and use the inquiry form, or contact our sales department directly with your requirements.
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