1-(tert-Butyldimethylsilyl)imidazole

CAS 54925-64-3C9H18N2SiChemical Synthesis

1-(tert-Butyldimethylsilyl)imidazole (CAS 54925-64-3), with the molecular formula C9H18N2Si and a molecular weight of 182.34 g/mol, is a versatile silylation reagent. It is commonly employed in organic synthesis as a protecting group for alcohols and other nucleophilic functional groups. Its utility extends to analytical chemistry, particularly in derivatization for gas chromatography (GC) to enhance volatility and thermal stability of analytes.

IUPAC: TBDMSIM

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1-(tert-Butyldimethylsilyl)imidazole (C9H18N2Si) — chemical structure, CAS 54925-64-3; Chemistry, fine chemical supplied by Tech Serve Solutions

Analytical ReagentsAnalytical/ChromatographyBuilding BlocksC9 to C30+Chemical SynthesisDerivatization ReagentsDerivatization Reagents GCHeterocyclic Building BlocksImidazolesReagents for Silylation

01 /Applications

Silylating Agent in Organic Synthesis

1-(tert-Butyldimethylsilyl)imidazole serves as an efficient reagent for introducing the tert-butyldimethylsilyl (TBDMS) protecting group onto alcohols, phenols, and other nucleophiles. This protection strategy is crucial in multi-step syntheses, preventing unwanted reactions at sensitive hydroxyl functionalities.

Derivatization for Gas Chromatography

In analytical chemistry, this compound is used to derivatize polar analytes, such as alcohols or amines, for gas chromatography (GC) analysis. The silylation process increases volatility and thermal stability, leading to improved chromatographic separation and detection.

Heterocyclic Building Block

As an imidazole derivative, it can function as a building block in the synthesis of more complex heterocyclic compounds with potential biological or material science applications.

02 /Properties

Molecular weight	182.34
Empirical formula	C9H18N2Si
Assay	97%
Grade	purum
Boiling point	53 °C/0.2 mmHg(lit.)
Density	0.939 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.481(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	99 °C / 210.2 °F
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

54925-64-3

MDL number

MFCD00011682

Beilstein registry

606695

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1-(tert-Butyldimethylsilyl)imidazole used for?

1-(tert-Butyldimethylsilyl)imidazole is primarily used as a silylating agent in organic synthesis to protect hydroxyl groups and as a derivatization reagent for gas chromatography (GC) analysis of volatile compounds.

What is the CAS number and formula for 1-(tert-Butyldimethylsilyl)imidazole?

The CAS number is 54925-64-3, and its molecular formula is C9H18N2Si.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 1-(tert-Butyldimethylsilyl)imidazole with a purity of 97% (grade: purum). We do not represent this product as USP, BP, or EP grade.

How should 1-(tert-Butyldimethylsilyl)imidazole be handled safely?

This compound is a skin, eye, and respiratory irritant. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure adequate ventilation. Refer to the Safety Data Sheet (SDS) for comprehensive safety information.

How is 1-(tert-Butyldimethylsilyl)imidazole packed, shipped, and exported?

Tech Serve Solutions packs, ships, and exports 1-(tert-Butyldimethylsilyl)imidazole according to international shipping regulations for chemical compounds. Specific packaging details can be provided upon request.

How can I request a sample or quote for 1-(tert-Butyldimethylsilyl)imidazole?

To request a sample or a quote for 1-(tert-Butyldimethylsilyl)imidazole, please contact our sales team through the website or by phone, providing your specific requirements.