1-(tert-Butoxycarbonyl)-5-methylindole
1-(tert-Butoxycarbonyl)-5-methylindole (CAS: 129822-49-7; Formula: C14H17NO2; MW: 231.29) is a valuable indole derivative used as a building block in organic synthesis. It serves as a reactant in the stereoselective preparation of substituted dihydroindole derivatives and in the conversion of indoles to oxindoles. This compound is essential for synthesizing complex molecules, including indolyl aromatic chiral alpha-sulfoxides and indolylborates.
- IUPAC
- tert-Butyl 5-methylindole-1-carboxylate
Preparation of Dihydroindole Derivatives
This compound acts as a key reactant in palladium-catalyzed stereoselective carboaminoxylation reactions, enabling the synthesis of complex substituted dihydroindole structures.
Synthesis of Oxindoles
It is utilised as a reactant in the conversion of 1-Boc-indoles to their corresponding 1-Boc-oxindole derivatives, a common transformation in medicinal chemistry.
Formation of Chiral Sulfoxides
This indole derivative is employed in the preparation of indolyl aromatic chiral alpha-sulfoxides, contributing to the synthesis of enantiomerically pure compounds.
Generation of Borates and Silanes
It serves as a reactant for preparing indolylborates, silanes, and silanols, expanding the range of functionalised indole derivatives.
| Molecular weight | 231.29 |
|---|---|
| Empirical formula | C14H17NO2 |
| Assay | 97% |
| Boiling point | 208-209 °C(lit.) |
| Density | 1.056 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5410(lit.) |
| Application | • Reactant in stereoselective preparation of substituted dihydroindole derivatives via palladium-catalyzed stereoselective carboaminoxylation reactions• Reactant in conversion of 1-Boc-indoles to 1-Boc-oxindoles• Reactant in preparation of indolyl aromatic chiral alpha-sulfoxides• Reactant in preparation of (indolyl)borates, silanes, and silanols |
Hazard statements
- H301Toxic if swallowed
- H317May cause an allergic skin reaction
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-43 |
| Safety statements (S) | 36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(tert-Butoxycarbonyl)-5-methylindole used for?
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1-(tert-Butoxycarbonyl)-5-methylindole is used as a reactant in various organic synthesis applications, including the preparation of substituted dihydroindole derivatives, the conversion of indoles to oxindoles, and the synthesis of indolyl aromatic chiral alpha-sulfoxides, indolylborates, silanes, and silanols.
What is the CAS number and molecular formula for 1-(tert-Butoxycarbonyl)-5-methylindole?
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The CAS number is 129822-49-7, and the molecular formula is C14H17NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(tert-Butoxycarbonyl)-5-methylindole with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 1-(tert-Butoxycarbonyl)-5-methylindole be handled safely?
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This compound is classified as toxic if swallowed and may cause an allergic skin reaction. Handling requires appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, face shields, and gloves. Refer to the safety data sheet for full details.
Is 1-(tert-Butoxycarbonyl)-5-methylindole available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 1-(tert-Butoxycarbonyl)-5-methylindole. We handle international shipments according to all regulations.
How can I request a quote or sample?
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To request a quote or sample of 1-(tert-Butoxycarbonyl)-5-methylindole, please contact our sales department through the website or by calling us directly.
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