1-Piperidinecarbonyl chloride
1-Piperidinecarbonyl chloride (CAS: 13939-69-0) is a chemical intermediate with the molecular formula C6H10ClNO and a molecular weight of 147.60 g/mol. This compound serves as a crucial reactant in organic synthesis, primarily utilized in the development of complex molecules. Its applications span across various research and development sectors, including pharmaceuticals and materials science, where it facilitates the construction of novel chemical entities.
- IUPAC
- N-Chloroformylpiperidine,NSC 50227
- Synonyms
- N-ChloroformylpiperidineNSC 50227
Pharmaceutical Intermediate Synthesis
Serves as a key reactant in the synthesis of various pharmaceutical agents, including dipeptidyl peptidase 4 inhibitors for type 2 diabetes and coumarin-based HIV-1 Vpr inhibitors.
Antitumor Agent Development
Utilised in the creation of antitumor agents that act as potent chemosensitizers, contributing to cancer research and therapeutic development.
Enzyme Inhibitor Research
Employed in the synthesis of oxime carbamates designed as reversible inhibitors of fatty acid amide hydrolase, and bisarylmaleimide inhibitors for glycogen synthase kinase-3.
Rare Disease Therapeutics
A precursor in the development of lysosomal acid lipase inhibitors, which hold potential as therapeutics for Niemann-Pick type C disease.
| Molecular weight | 147.60 |
|---|---|
| Empirical formula | C6H10ClNO |
| Assay | 97% |
| Boiling point | 242 °C(lit.) |
| Density | 1.18 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.459(lit.) |
| Application | Reactant for synthesis of: A coumarin-based HIV-1 Vpr inhibitor1 Antitumor agents as potent chemosensitizers2 Oxime carbamates as reversible inhibitors of fatty acid amide hydrolase3 Dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes4 Bisarylmaleimide glycogen synthase kinase-3 inhibitors5 Lysosomal acid lipase inhibitors and potential Niemann-Pick type C disease therapeutics6 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Piperidinecarbonyl chloride used for?
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1-Piperidinecarbonyl chloride is primarily used as a reactant in the synthesis of various compounds, including pharmaceutical agents like HIV-1 Vpr inhibitors, antitumor agents, enzyme inhibitors (e.g., fatty acid amide hydrolase inhibitors, glycogen synthase kinase-3 inhibitors), and potential therapeutics for Niemann-Pick type C disease.
What is the CAS number and formula for 1-Piperidinecarbonyl chloride?
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The CAS number for 1-Piperidinecarbonyl chloride is 13939-69-0, and its empirical formula (Hill notation) is C6H10ClNO.
What grade and purity does Tech Serve Solutions supply for 1-Piperidinecarbonyl chloride?
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Tech Serve Solutions supplies 1-Piperidinecarbonyl chloride with an assay of 97%. This product is supplied for research and development purposes and is not guaranteed to be of USP, BP, EP, or other pharmacopoeia grade.
What are the primary safety hazards associated with 1-Piperidinecarbonyl chloride?
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1-Piperidinecarbonyl chloride is classified with Danger as a signal word and carries the hazard statement H314, indicating it causes severe skin burns and eye damage. Appropriate personal protective equipment, including face shields, gloves, and respirators, is essential during handling.
How is 1-Piperidinecarbonyl chloride packed, shipped, and exported by Tech Serve Solutions?
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1-Piperidinecarbonyl chloride is packed and shipped in compliance with UN 3265, Hazard Class 8, Packing Group III regulations, suitable for global export by Tech Serve Solutions.
How can I request a sample or quote for 1-Piperidinecarbonyl chloride?
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To request a sample or obtain a quote for 1-Piperidinecarbonyl chloride, please contact our sales team through the TSS website or direct inquiry.
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