1-Naphthalenesulfonyl chloride
1-Naphthalenesulfonyl chloride (CAS: 85-46-1; Formula: C10H7ClO2S; Molar Mass: 226.68 g/mol) is a key organic building block and sulfonyl halide. Utilised in organic synthesis, it is an important intermediate for preparing various naphthalene derivatives and other complex molecules. Its reactivity makes it valuable in the development of new chemical entities for research and industrial applications. This compound is supplied by TSS for laboratory and manufacturing purposes.
Nucleoside and Nucleotide Modification
1-Naphthalenesulfonyl chloride is employed in the synthesis of modified nucleosides, such as 5′-O-naphthalenesulfonyldeoxyuridine. This application is relevant in biochemical research and the development of therapeutic agents.
Synthesis of Indazole Derivatives
This reagent serves as a precursor for generating 1-sulfonylindazole derivatives. These compounds can have diverse applications in medicinal chemistry and materials science due to their unique structural features.
Organic Synthesis Intermediate
As a versatile sulfonyl halide, 1-Naphthalenesulfonyl chloride is widely used as a building block in complex organic syntheses. It facilitates the introduction of the naphthalenesulfonyl group into various organic molecules.
| Molecular weight | 226.68 |
|---|---|
| Empirical formula | C10H7ClO2S |
| Assay | 97% |
| Boiling point | 194-195 °C/13 mmHg(lit.) |
| Solubility | chloroform: soluble25 mg/mL, clear to very slightly hazy, colorless to yellow |
| Application | 1-Naphthalenesulfonyl chloride has been used in the preparation of:• 5′-O-naphthaleneiulfonyldeoxyuridine1• 1-sulfonylindazole derivatives2 |
| Melting point | 64-67 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Naphthalenesulfonyl chloride used for?
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1-Naphthalenesulfonyl chloride is used as a building block in organic synthesis, notably in the preparation of modified nucleosides (e.g., 5′-O-naphthalenesulfonyldeoxyuridine) and 1-sulfonylindazole derivatives. It is a key intermediate for introducing the naphthalenesulfonyl moiety into organic molecules.
What are the CAS number and formula for 1-Naphthalenesulfonyl chloride?
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The CAS number for 1-Naphthalenesulfonyl chloride is 85-46-1, and its empirical formula (Hill notation) is C10H7ClO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Naphthalenesulfonyl chloride with a minimum assay of 97%. This product is suitable for research and general chemical synthesis; TSS does not represent it as USP, BP, EP, or pharmaceutical grade.
How should 1-Naphthalenesulfonyl chloride be handled safely?
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1-Naphthalenesulfonyl chloride is classified as corrosive (Danger, H314). Handling requires stringent safety measures, including chemical-resistant gloves, eye and face protection (e.g., goggles, face shield), and appropriate respiratory protection (e.g., N100 respirator). Work should be conducted in a well-ventilated area or fume hood. Refer to the Safety Data Sheet for comprehensive guidance.
Is 1-Naphthalenesulfonyl chloride a controlled substance?
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The provided data does not indicate that 1-Naphthalenesulfonyl chloride is a controlled or scheduled substance.
How is 1-Naphthalenesulfonyl chloride packed and exported?
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1-Naphthalenesulfonyl chloride is carefully packed in compliance with international shipping regulations for hazardous materials (UN 3261, Class 8, Packing Group II). TSS expertly handles the export documentation and logistics to ensure safe and compliant global delivery.
How can I request a sample or quote for 1-Naphthalenesulfonyl chloride?
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To request a sample or a quote for 1-Naphthalenesulfonyl chloride, please contact our sales team via the website or direct email, providing your specific requirements.
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