1-Methylindole-5-boronic acid pinacol ester
1-Methylindole-5-boronic acid pinacol ester (CAS: 837392-62-8; Formula: C15H20BNO2; Molar Mass: 257.14 g/mol) is a valuable organoboron compound. Utilised as a key building block in organic synthesis, it primarily finds application in cross-coupling reactions. Its structure makes it suitable for introducing the 1-methylindole moiety into complex molecules, contributing to the development of novel chemical entities in research and development.
- IUPAC
- 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole,1-Methyl-5-indoleboronic acid pinacol ester
- Synonyms
- 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
Suzuki-Miyaura Cross-Coupling Reactions
This boronate ester serves as an effective coupling partner in Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds, enabling the synthesis of diverse biaryl and heteroaryl compounds relevant to medicinal chemistry and materials science.
Organic Synthesis Building Block
As a functionalised indole derivative, it is employed in multi-step syntheses. Its pinacol ester group offers stability and good reactivity, making it a preferred choice for constructing complex organic frameworks.
Medicinal Chemistry Research
The 1-methylindole core is present in various biologically active molecules. This compound is therefore useful for the preparation of novel drug candidates and for structure-activity relationship (SAR) studies in pharmaceutical research.
| Molecular weight | 257.14 |
|---|---|
| Empirical formula | C15H20BNO2 |
| Assay | 97% |
| Melting point | 110-114 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Methylindole-5-boronic acid pinacol ester used for?
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1-Methylindole-5-boronic acid pinacol ester is primarily used as a building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, to introduce the 1-methylindole moiety into target molecules for medicinal chemistry and materials science research.
What are the CAS number and molecular formula?
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The CAS number is 837392-62-8 and the molecular formula is C15H20BNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Methylindole-5-boronic acid pinacol ester with a minimum assay of 97%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or pharmaceutical grade.
What safety precautions should be taken when handling this chemical?
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When handling 1-Methylindole-5-boronic acid pinacol ester, appropriate personal protective equipment should be worn, including eyeshields and gloves. A respirator filter suitable for particulates (type N95 or P1) is recommended. Ensure adequate ventilation.
Is this chemical classified as hazardous in Germany?
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Yes, this chemical has a WGK Germany classification of 3, indicating a high level of hazard.
How can I request a quote or sample?
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To request a quote or a sample of 1-Methylindole-5-boronic acid pinacol ester, please visit the Tech Serve Solutions website or contact our sales team directly with your inquiry.
Is this product shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and we can arrange for the shipment and export of 1-Methylindole-5-boronic acid pinacol ester worldwide, subject to applicable regulations.
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