1-Methylindole-3-carboxylic acid
1-Methylindole-3-carboxylic acid (CAS: 32387-21-6, C10H9NO2) is a heterocyclic building block with a molecular weight of 175.18 g/mol. This compound serves as a key reactant in the synthesis of various biologically active molecules. Its applications are primarily found in medicinal chemistry research, enabling the preparation of potential therapeutic agents targeting enzymes and receptors involved in disease pathways, including kinase inhibitors and receptor antagonists.
Preparation of Kinase Inhibitors
This compound is used as a reactant in the synthesis of (heteroaryl)(carboxamido)arylpyrrole derivatives, which have demonstrated activity as Cdc7 kinase inhibitors with potential antitumor and antiproliferative properties.
Synthesis of Receptor Antagonists
It serves as a reactant for preparing pyrazolodiazepine derivatives evaluated as antagonists for the human P2X7 receptor, a target in inflammatory conditions.
Development of Receptor Agonists
1-Methylindole-3-carboxylic acid is employed in the synthesis of potent nonpeptidic urotensin II receptor agonists, investigated for their therapeutic potential.
Ligand Synthesis for Serotonin Receptors
The compound is a reactant in the preparation of pyrrolizidine esters, amides, and ureas, which function as 5-HT4 receptor ligands.
| Molecular weight | 175.18 |
|---|---|
| Empirical formula | C10H9NO2 |
| Assay | 97% |
| Application | • Reactant for preparation of bisindolyl pyrimidinones analogs of PKC inhibitor LY3335311• Reactant for preparation of (heteroaryl)(carboxamido)arylpyrrole derivatives as Cdc7 kinase inhibitors, antitumor and antiproliferative agents2• Reactant for preparation of (pyrrolidinylmethoxy)cyclohexanecarboxylic acids as antigen-4 (VLA-4) antagonists3• Reactant for preparation of EphB3 receptor tyrosine kinase inhibitors4• Reactant for preparation of pyrazolodiazepine derivatives as human P2X7 receptor antagonists5• Reactant for preparation of potent nonpeptidic urotensin II receptor agonists6• Reactant for preparation of pyrrolizidine esters, amides, and ureas as 5-HT4 receptor ligands7 |
| Melting point | 197-200 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Methylindole-3-carboxylic acid used for?
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1-Methylindole-3-carboxylic acid is used as a reactant in organic synthesis, particularly in the preparation of potential pharmaceutical agents such as kinase inhibitors, receptor antagonists, receptor agonists, and receptor ligands.
What are the CAS number and formula for 1-Methylindole-3-carboxylic acid?
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The CAS number is 32387-21-6 and the empirical formula is C10H9NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Methylindole-3-carboxylic acid with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 1-Methylindole-3-carboxylic acid be handled safely?
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Based on GHS information, this compound is a Warning with hazard statements H315, H319, and H335, indicating it causes skin irritation, serious eye irritation, and may cause respiratory irritation. Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area.
Is 1-Methylindole-3-carboxylic acid a controlled substance?
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The provided data does not indicate that 1-Methylindole-3-carboxylic acid is a controlled substance.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions, a global supplier and exporter, handles packing, shipping, and export of chemicals in compliance with international regulations to ensure safe and secure delivery worldwide.
How can I request a sample or quote for 1-Methylindole-3-carboxylic acid?
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To request a sample or quote, please contact our sales department through the website or by phone, providing the product name and CAS number.
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