1-Methylindole-3-carboxaldehyde

CAS 19012-03-4C10H9NOChemical Synthesis

1-Methylindole-3-carboxaldehyde (CAS 19012-03-4, C10H9NO, MW 159.18) is a key organic building block featuring an indole core functionalised with an aldehyde group. This compound serves as a versatile reactant in various synthetic organic chemistry applications, notably in the preparation of diverse heterocyclic compounds and biologically relevant molecules. It is supplied by Tech Serve Solutions with a purity of 97%.

IUPAC: 3-Formyl-1-methylindole,NSC 83042

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1-Methylindole-3-carboxaldehyde (C10H9NO) — chemical structure, CAS 19012-03-4; Chemistry, fine chemical supplied by Tech Serve Solutions

AldehydesBuilding BlocksC10C10-C12Carbonyl CompoundsChemical SynthesisHeterocyclic Building BlocksIndoles

01 /Applications

Henry and Ugi Reactions

Utilised as a reactant in microwave- or ultrasound-assisted Henry reactions for the preparation of nitroolefins and β-nitroalcohols. It also participates in three-component Ugi reactions for the synthesis of quinolinones.

Synthesis of Bioactive Compounds

Serves as a reactant in the synthesis of α-ketoamides, which are investigated as inhibitors of Dengue virus protease for antiviral activity. It is also employed in preparing thiazolopyrimidinones, potential inhibitors of Bcl-2 proteins.

Preparation of Indole Derivatives

Reactant for the preparation of vinylindoles via Peterson olefination or Nysted reagent olefination. It is also used in microwave-enhanced Knoevenagel condensation to yield indolyl alkenes with antibacterial properties.

02 /Properties

Molecular weight	159.18
Empirical formula	C10H9NO
Assay	97%
Application	• Reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions1• Reactant for synthesis of quinolinones via three-component Ugi reaction2• Reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture3• Reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins4• Reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent5• Reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents6
Melting point	70-72 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-37/39

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

19012-03-4

MDL number

MFCD00014570

PubChem substance

24861954

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1-Methylindole-3-carboxaldehyde used for?

1-Methylindole-3-carboxaldehyde is used as a reactant in various organic syntheses, including the preparation of nitroolefins, β-nitroalcohols, quinolinones, α-ketoamides, thiazolopyrimidinones, and indolyl alkenes.

What is the CAS number and chemical formula for 1-Methylindole-3-carboxaldehyde?

The CAS number is 19012-03-4 and the chemical formula is C10H9NO.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 1-Methylindole-3-carboxaldehyde with an assay of 97%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.

What are the primary safety considerations when handling this chemical?

1-Methylindole-3-carboxaldehyde is classified as an irritant to the skin, eyes, and respiratory tract (H315, H319, H335). Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, in a well-ventilated area.

How is this chemical typically packed, shipped, or exported?

We ensure secure and compliant packaging for all our chemicals, adhering to international shipping and export regulations. Specific packing details are available upon request.