1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidinone (CAS 872-50-4, C5H9NO) is a versatile, aprotic solvent with a low vapour pressure and high boiling point. It is miscible with water and many organic solvents, making it highly effective in various chemical applications. Its excellent solvency power makes it a preferred choice for processes in chemical synthesis, chemical biology, and peptide chemistry. Tech Serve Solutions offers this compound with exceptional purity, meeting stringent quality standards for demanding research and industrial uses.
- IUPAC
- 1-Methyl-2-pyrrolidone,N-Methyl-2-pyrrolidone,NMP
- Synonyms
- 1-Methyl-2-pyrrolidoneN-Methyl-2-pyrrolidoneNMP
Chemical Synthesis
1-Methyl-2-pyrrolidinone serves as a powerful polar aprotic solvent in numerous organic reactions. Its ability to dissolve a wide range of organic and inorganic compounds facilitates reaction kinetics and improves yields in complex synthetic pathways.
Chemical Biology
This solvent is utilised in biochemical research for solubilising biomolecules and in various biological assays. Its properties are valuable for sample preparation and processing in diverse chemical biology investigations.
Peptide Synthesis
As a high-purity solvent, 1-Methyl-2-pyrrolidinone is extensively used in solid-phase and solution-phase peptide synthesis. It effectively dissolves protected amino acids and peptides, supporting efficient coupling and deprotection steps.
Industrial Applications
Beyond research, NMP is employed in industrial processes such as polymer production, surface coating, and electronics manufacturing due to its excellent solvency and stability.
| Molecular weight | 99.13 |
|---|---|
| Empirical formula | C5H9NO |
| Assay | ≥99.0% (GC) |
| Grade | SAJ first grade |
| Boiling point | 202 °C(lit.)81-82 °C/10 mmHg(lit.) |
| Density | 1.028 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.47(lit.)n20/D 1.470 |
| Melting point | −24 °C(lit.) |
| Vapour pressure | 0.29 mmHg (20 °C)0.99 mmHg (40 °C) |
| Vapour density | 3.4 (vs air) |
| Autoignition temp | 518 °F |
| Impurities tested | ≤0.1% water |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H360D
Precautionary statements
- P201Obtain special instructions before use
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 91 °C / 195.8 °F |
| Transport (UN / ADR) | UN 1993 / PGIII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | T |
| Risk statements (R) | 61-36/37/38 |
| Safety statements (S) | 53-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Expl Lim | 9.5 % |
|---|---|
| Availability | available only in Japan |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Methyl-2-pyrrolidinone used for?
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1-Methyl-2-pyrrolidinone is primarily used as a solvent in chemical synthesis, chemical biology, and peptide chemistry. It also finds applications in industrial processes like polymer production and surface coatings.
What is the CAS number and chemical formula for 1-Methyl-2-pyrrolidinone?
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The CAS number is 872-50-4 and the chemical formula is C5H9NO.
What grade and purity does Tech Serve Solutions supply for 1-Methyl-2-pyrrolidinone?
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Tech Serve Solutions supplies 1-Methyl-2-pyrrolidinone in SAJ first grade with an assay of ≥99.0% (GC) and ≤0.1% water. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for 1-Methyl-2-pyrrolidinone?
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1-Methyl-2-pyrrolidinone is labelled with GHS07 and GHS08 symbols and carries a Danger signal word. It is classified with hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation), H335 (may cause respiratory irritation), and H360D (may damage the unborn child). Always consult the Safety Data Sheet (SDS) and use appropriate personal protective equipment, including eyeshields and chemical-resistant gloves, in a well-ventilated area. Follow precautionary statements P201, P261, P305 + P351 + P338, and P308 + P313.
Is 1-Methyl-2-pyrrolidinone available only in Japan?
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Yes, this specific grade (SAJ first grade) is available only in Japan.
How can I request a sample or quote for 1-Methyl-2-pyrrolidinone?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by phone, providing the product name and CAS number.
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