1-Fluoronaphthalene
1-Fluoronaphthalene (CAS 321-38-0), with the molecular formula C10H7F and a molecular weight of 146.16 g/mol, is a fluorinated aromatic compound. It serves as a valuable building block in organic synthesis. This chemical is utilized in the development of various organic molecules, including pharmaceuticals and research compounds, leveraging its specific reactivity in synthetic pathways.
Organic Synthesis Intermediate
1-Fluoronaphthalene is employed as a key intermediate in complex organic syntheses. Its fluorinated structure allows for specific chemical transformations, making it useful for introducing fluorine into target molecules.
Pharmaceutical Research
This compound has been utilised in the synthesis of pharmaceutical agents. Notably, it played a role in the development of molecules targeting neurotransmitter reuptake, such as LY248686, a serotonin and norepinephrine reuptake inhibitor.
Building Block for Heterocycles
1-Fluoronaphthalene has been used in the synthesis of substituted phenanthridines. Reactions involving organolithium reagents can be employed to construct these fused heterocyclic systems.
| Molecular weight | 146.16 |
|---|---|
| Empirical formula | C10H7F |
| Assay | 99% |
| Boiling point | 215 °C(lit.) |
| Density | 1.1322 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.593(lit.) |
| Application | 1-Fluoronaphthalene was used in t-BuLi-mediated synthesis of 6-substituted phenanthridines1. It was also used in the synthesis of LY248686, a potent inhibitor of serotonin and norepinephrine uptake2. |
| Melting point | −13 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 65 °C / 149 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Fluoronaphthalene used for?
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1-Fluoronaphthalene is used as an intermediate in organic synthesis, particularly in the preparation of pharmaceuticals and complex organic molecules, including substituted phenanthridines.
What are the CAS number and formula for 1-Fluoronaphthalene?
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The CAS number for 1-Fluoronaphthalene is 321-38-0, and its empirical formula is C10H7F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Fluoronaphthalene with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should 1-Fluoronaphthalene be handled safely?
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1-Fluoronaphthalene is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure good ventilation.
How is 1-Fluoronaphthalene packed and shipped?
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1-Fluoronaphthalene is shipped according to regulations for flammable liquids and hazardous substances, typically in UN-approved packaging.
How can I request a quote or sample of 1-Fluoronaphthalene?
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To request a quote or sample of 1-Fluoronaphthalene, please contact our sales department through the website or by phone.
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