1-Fluoro-4-nitrobenzene
1-Fluoro-4-nitrobenzene (CAS: 350-46-9), with the molecular formula C6H4FNO2 and a molar mass of 141.10 g/mol, is a fluorinated aromatic compound. It serves as a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. Its distinct structure, featuring both a nitro group and a fluorine atom on a benzene ring, allows for versatile chemical transformations.
Pharmaceutical Intermediate
Utilised in the synthesis of active pharmaceutical ingredients (APIs). The presence of the fluorine atom can influence drug properties such as metabolic stability and bioavailability.
Agrochemical Synthesis
A key building block for the creation of various pesticides and herbicides. Its reactive sites allow for the introduction of complex functionalities required for crop protection agents.
Research and Development
Employed in academic and industrial research laboratories for the exploration of novel chemical entities and reaction pathways.
Organic Synthesis
Serves as a versatile synthon for introducing the 4-nitrophenyl group or undergoing nucleophilic aromatic substitution reactions due to the activating nitro group and the leaving-group potential of fluorine.
| Molecular weight | 141.10 |
|---|---|
| Linear formula | FC6H4NO2 |
| Assay | ≥98.0% (GC) |
| Boiling point | 205 °C(lit.) |
| Density | 1.33 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.531(lit.) |
| Vapour pressure | 5.5 mmHg (70 °C) |
| Melting point | 21 °C(lit.) |
| Vapour density | >1 (vs air) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H331Toxic if inhaled
- H373May cause damage to organs through prolonged exposure
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 90 °C / 194 °F |
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-33 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Fluoro-4-nitrobenzene used for?
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1-Fluoro-4-nitrobenzene is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as in general organic synthesis and research and development.
What is the CAS number and chemical formula for 1-Fluoro-4-nitrobenzene?
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The CAS number is 350-46-9 and the chemical formula is C6H4FNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Fluoro-4-nitrobenzene with an assay of ≥98.0% (GC). This product is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
How is 1-Fluoro-4-nitrobenzene handled and shipped?
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1-Fluoro-4-nitrobenzene is classified as dangerous and requires careful handling. It is shipped according to UN 2811, 6.1 / PGIII regulations, necessitating appropriate safety precautions and adherence to transport guidelines.
What are the main hazards associated with 1-Fluoro-4-nitrobenzene?
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This compound is hazardous, with danger signals including GHS06 and GHS08. It is harmful if swallowed (H302), harmful in contact with skin (H312), toxic if inhaled (H331), and may cause damage to organs through prolonged or repeated exposure (H373). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, is essential.
How can I request a sample or quote for 1-Fluoro-4-nitrobenzene?
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To request a sample or quote, please contact our sales team through the website or by phone. Provide the product name and CAS number for prompt service.
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