1,4-Bis(diphenylphosphino)butane
1,4-Bis(diphenylphosphino)butane (CAS 7688-25-7), a white crystalline solid with the formula (C6H5)2P(CH2)4P(C6H5)2 and a molecular weight of 426.47 g/mol, is a vital bisphosphine ligand. It is widely employed in organometallic chemistry and homogeneous catalysis, particularly in transition metal-catalyzed cross-coupling reactions and various synthetic transformations. Its bidentate nature allows it to form stable chelate complexes with metals.
- IUPAC
- 1,4-Butanediylbis[diphenylphosphine],1,4-Butylenebis(diphenylphosphine),Tetramethylenebis(diphenylphosphine),dppb
- Synonyms
- (C6H5)2P(CH2)4P(C6H5)21,4-Butanediylbis[diphenylphosphine]1,4-Butylenebis(diphenylphosphine)Tetramethylenebis(diphenylphosphine)dppb
Homogeneous Catalysis
1,4-Bis(diphenylphosphino)butane serves as a crucial ligand in homogeneous catalysis, forming complexes with transition metals like palladium, nickel, and rhodium. These complexes are active catalysts for a variety of organic transformations.
Cross-Coupling Reactions
This phosphine ligand is extensively used in palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura, Heck, Sonogashira, Stille, and Negishi couplings, facilitating the formation of carbon-carbon bonds.
Isomerization Reactions
Complexes derived from 1,4-Bis(diphenylphosphino)butane can catalyse the isomerization of alkenes and other functional groups, offering pathways for molecular rearrangement in organic synthesis.
Ligand for Metal Complexes
Its ability to act as a chelating ligand makes it valuable for stabilising metal centres and tuning their reactivity in organometallic chemistry research and development.
| Molecular weight | 426.47 |
|---|---|
| Linear formula | (C6H5)2P(CH2)4P(C6H5)2 |
| Assay | 98% |
| Grade | purum |
| Melting point | 132-136 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H413May cause long-lasting harmful effects to aquatic life
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | AlkylationsHeck ReactionIsomerizationsNegishi CouplingSonogashira CouplingStille CouplingSuzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,4-Bis(diphenylphosphino)butane used for?
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1,4-Bis(diphenylphosphino)butane is primarily used as a bidentate phosphine ligand in homogeneous catalysis, particularly for transition metal-catalyzed cross-coupling reactions like Suzuki-Miyaura, Heck, Sonogashira, Stille, and Negishi couplings, as well as for isomerisation reactions.
What are the CAS number and formula for 1,4-Bis(diphenylphosphino)butane?
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The CAS number for 1,4-Bis(diphenylphosphino)butane is 7688-25-7, and its linear formula is (C6H5)2P(CH2)4P(C6H5)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,4-Bis(diphenylphosphino)butane in 'purum' grade with an assay of 98%.
How should 1,4-Bis(diphenylphosphino)butane be handled safely?
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Handle with care, using a dust mask type N95 (US), eyeshields, and gloves. This compound is a warning hazard (GHS07), causing skin and eye irritation (H315, H319) and may cause long lasting harmful effects to aquatic life (H413).
How is this chemical packed and shipped?
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Tech Serve Solutions can export this chemical globally. Packing adheres to international shipping regulations for fine chemicals.
How can I request a sample or quote for 1,4-Bis(diphenylphosphino)butane?
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Please contact our sales team through the website or by phone to request a sample or a quotation for 1,4-Bis(diphenylphosphino)butane.
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