1-(3-Methylbenzyl)piperazine
1-(3-Methylbenzyl)piperazine (CAS 5321-48-2) is an N-substituted piperazine building block with the molecular formula C12H18N2 and a molecular weight of 190.28 g/mol. It is a mono-benzylated piperazine bearing a 3-methylbenzyl group, typically supplied as a liquid with a free secondary amine. Tech Serve Solutions supplies it as a research-grade synthesis intermediate for medicinal chemistry and the preparation of more complex piperazine derivatives.
- Synonyms
- 1-(3-Methylbenzyl)piperazine1-(3-methylbenzyl)piperazine1-(3-Methylbenzyl)-piperazine3-Methylbenzylpiperazine1-(m-Methylbenzyl)piperazineCAS 5321-48-2
Heterocyclic building block
Serves as a piperazine scaffold in organic and medicinal chemistry. The free secondary N-H provides a reactive site for alkylation, acylation, sulfonylation and reductive amination to build more elaborate structures.
Pharmaceutical intermediate research
Used as an intermediate in the laboratory synthesis of substituted piperazine compounds. The N-benzylpiperazine motif is a recurring fragment in medicinal chemistry discovery programmes.
Chemical synthesis and derivatisation
Acts as a precursor for preparing salts, amides and other N-functionalised piperazine derivatives. Its single free amine allows selective mono-functionalisation.
Reference and laboratory reagent
Supplied for analytical, method-development and structure-activity research where a defined 3-methylbenzyl piperazine is required. Provided as a research-grade reagent, not for therapeutic use.
| Molecular weight | 190.28 |
|---|---|
| Empirical formula | C12H18N2 |
| Assay | 97% |
| Boiling point | 256-257 °C(lit.) |
| Density | 1.001 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5400(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Methylbenzyl)piperazine used for?
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It is used mainly as a building block and synthesis intermediate in organic and medicinal chemistry. The piperazine ring carries a 3-methylbenzyl group and a free secondary amine, making it a versatile precursor for alkylation, acylation and reductive amination to access substituted piperazine derivatives. It is supplied for research and manufacturing use, not for therapeutic application.
What is the CAS number and molecular formula of 1-(3-Methylbenzyl)piperazine?
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The CAS number is 5321-48-2 and the molecular formula is C12H18N2, with a molecular weight of 190.28 g/mol. The EC number is 226-184-4 and the MDL number is MFCD01321003. It is commonly supplied as a liquid (boiling point 256-257 °C, density approximately 1.001 g/mL at 25 °C).
What grade and purity does Tech Serve Solutions supply?
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We supply 1-(3-Methylbenzyl)piperazine at a typical assay of 97% as a research/technical-grade reagent and synthesis intermediate. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch, and specific purity or specification requirements can be discussed on enquiry.
What are the safety and handling requirements?
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It is classified under GHS07 with the signal word Warning. The hazard statements are H302 (harmful if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves and eye protection, avoid generating dust or mist (use a suitable respirator such as N95), and work with adequate ventilation. Relevant precautions include P261 and P305+P351+P338. It is assigned WGK 2 (water hazard). Always consult the Safety Data Sheet before use.
How is 1-(3-Methylbenzyl)piperazine packed, shipped and exported?
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It is packed in appropriately sealed containers sized to the order, with full labelling and documentation. As an exporter since 1998, Tech Serve Solutions arranges compliant international shipping with a certificate of analysis, Safety Data Sheet and the transport paperwork required for your destination. Packaging and consignment details are confirmed at the time of order.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity specification and destination country, and we will respond with availability, lead time and quotation. Samples can be arranged where appropriate to support your evaluation.
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