1-(2-Fluorobenzyl)piperazine
1-(2-Fluorobenzyl)piperazine (CAS 89292-78-4) is a fluorinated piperazine building block with the molecular formula C11H15FN2 and a molar mass of 194.25 g/mol. It pairs a secondary piperazine ring with an ortho-fluorobenzyl group, giving a versatile, basic nitrogen-bearing scaffold widely used in pharmaceutical and chemical synthesis. Tech Serve Solutions supplies it as a research-grade reagent (typically 96% assay) for laboratory and process development applications worldwide.
- Synonyms
- 1-(2-Fluorobenzyl)piperazine1-(2-fluorobenzyl)piperazine2-fluorobenzylpiperazine1-[(2-fluorophenyl)methyl]piperazineN-(2-fluorobenzyl)piperazine
Pharmaceutical intermediate
Serves as a versatile intermediate in the preparation of active pharmaceutical ingredients and candidate molecules. The reactive secondary amine on the piperazine ring is a common point for further functionalisation.
Fluorinated building block
Used in medicinal and synthetic chemistry to introduce an ortho-fluorobenzyl moiety into target structures. Fluorine substitution is a well-established strategy for tuning metabolic stability, lipophilicity and binding properties.
Heterocyclic scaffold for synthesis
The piperazine core is a privileged heterocycle in drug discovery, frequently incorporated to modulate solubility and pharmacology. This compound provides a ready-made, mono-substituted piperazine handle for library and analogue synthesis.
Research and laboratory reagent
Supplied as a research-grade reagent for exploratory and process-development chemistry. Suitable for use as a starting material in alkylation, acylation and reductive-amination reactions at the free N-H position.
| Molecular weight | 194.25 |
|---|---|
| Empirical formula | C11H15FN2 |
| Assay | 96% |
| Boiling point | 93-96 °C/0.2 mmHg(lit.) |
| Density | 1.170 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5330(lit.) |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Fluorobenzyl)piperazine used for?
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It is used principally as a building block and intermediate in pharmaceutical and chemical synthesis. The mono-substituted piperazine ring bears a free secondary amine that is readily elaborated, while the ortho-fluorobenzyl group introduces fluorine into target molecules for medicinal-chemistry purposes.
What is the CAS number and molecular formula of 1-(2-Fluorobenzyl)piperazine?
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The CAS number is 89292-78-4 and the molecular formula is C11H15FN2 (Hill notation), corresponding to a molecular weight of 194.25 g/mol. The MDL number is MFCD02256027.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-(2-Fluorobenzyl)piperazine as a research/technical-grade reagent at a typical assay of 96%. It is not represented as USP, BP or EP pharmacopoeia grade. A certificate of analysis can be provided with each batch, and specifications can be confirmed against your requirements at the time of enquiry.
What are the safety and handling requirements for 1-(2-Fluorobenzyl)piperazine?
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It is classified under GHS07 with the signal word Warning and hazard statement H319 (causes serious eye irritation). Wear eye protection and gloves, and use suitable respiratory protection where mists or vapours may form. If it gets in the eyes, rinse cautiously with water for several minutes, remove contact lenses if present and continue rinsing (P305 + P351 + P338). It is assigned German Water Hazard Class (WGK) 3, so prevent release to drains and watercourses. Always consult the Safety Data Sheet before use.
How is 1-(2-Fluorobenzyl)piperazine packed, shipped and exported?
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The material is packed in appropriately sealed containers sized from laboratory quantities to bulk, with packaging selected to suit the order and destination. As a specialist exporter since 1998, Tech Serve Solutions handles documentation, labelling and compliant international shipping; exact pack sizes and logistics are confirmed at the time of order.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and delivery destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for evaluation where appropriate.
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