1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate
1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate (CAS: 213343-64-7) is a rhodium-based chiral catalyst complex. With the empirical formula C30H48BF4P2Rh and a molecular weight of 660.36 g/mol, it is primarily utilised in asymmetric synthesis. This compound is a valuable tool for enantioselective preparation of various organic molecules, including amino acid derivatives and precursors for pharmaceutical applications.
- IUPAC
- (S,S)-Et-DUPHOS-Rh
- Synonyms
- (S,S)-Et-DUPHOS-Rh(1,5-Cyclooctadiene)[1,2-bis((2S,5S)-2,5-diethylphospholano)benzene]rhodium(I) tetrafluoroborate
![1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate (5S)-2) — chemical structure, CAS 213343-64-7; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F213343-64-7.png&w=3840&q=75)
Asymmetric Hydrogenation Catalysis
This rhodium complex acts as an effective catalyst for the asymmetric hydrogenation of various substrates. It is instrumental in preparing chiral intermediates, such as precursors for cryptophycins and constrained phenylalanine analogues.
Synthesis of Amino Acid Derivatives
The catalyst facilitates the enantioselective synthesis of N-benzyloxy-β-amino acid methyl esters. It also aids in the preparation of fluoro amino acids, which serve as synthons for potent macrocyclic HCV NS3 protease inhibitors.
Preparation of Labelled Compounds
It is employed in the stereoselective preparation of triply isotope-labeled amino acids like Ser, Cys, and Ala, crucial for metabolic studies and tracer development.
| Molecular weight | 660.36 |
|---|---|
| Empirical formula | C30H48BF4P2Rh |
| Application | DuPhos and BPE Ligands: Highly Efficient Privileged LigandsCatalyst for:• Preparation of a key unit B precursor of cryptophycins via Horner-Wadsworth-Emmons reaction and asymmetric hydrogenation1• Preparation of constrained phenylalanine analogs via Heck reaction followed by asymmetric hydrogenation and cyclization steps2• Enantioselective preparation of N-benzyloxy-β-amino acid Me esters by hydrogenation of α-(benzyloxyaminomethyl)acrylate stereoisomers3• Preparation of fluoro amino acids as synthons for potent macrocyclic HCV NS3 protease inhibitors4• Stereoselective preparation of triply isotope-labeled Ser, Cys, and Ala5• Preparation of β-amino acids from asymmetric hydrogenation of α-(aminometh |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate used for?
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This compound is a rhodium-based chiral catalyst primarily used in asymmetric synthesis for the enantioselective preparation of various organic molecules, including amino acid derivatives and precursors for pharmaceutical research.
What is the CAS number and formula for this rhodium catalyst?
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The CAS number is 213343-64-7, and the empirical formula is C30H48BF4P2Rh.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a research or technical grade chemical. We do not represent it as USP, BP, EP, or any other pharmacopoeia grade. Purity information is available upon request.
How should this chemical be handled?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. This compound is classified under WGK 3 in Germany, indicating a high hazard to water.
Is this chemical shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, including this compound.
How can I request a quote or sample?
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Please contact our sales team directly via the website or by phone to request a quotation or a sample of this chemical.
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