Tetramethylrhodamine-6-maleimide
Tetramethylrhodamine-6-maleimide (CAS: 174568-68-4, C28H23N3O5) is a rhodamine derivative utilized as a fluorescent label. With a molecular weight of 481.50, this compound is specifically designed for the selective labeling of sulfhydryl groups (thiols) in biomolecules. Its fluorescent properties make it valuable in various biochemical and molecular biology applications for detection and imaging purposes. TSS supplies this reagent for research and development activities.
Fluorescent Labeling of Proteins
Tetramethylrhodamine-6-maleimide reacts with cysteine residues (sulfhydryl groups) in proteins to introduce a fluorescent tag. This allows for the visualization and quantification of proteins in biological samples using fluorescence microscopy or spectroscopy.
Bioconjugation and Assay Development
The maleimide functionality enables covalent attachment to thiol-containing molecules, facilitating the creation of fluorescently labeled peptides, antibodies, or other biomolecules for use in assays, diagnostics, and targeted drug delivery research.
Molecular Biology Research
This reagent is instrumental in studies involving protein structural analysis and proteomic investigations where precise labeling of specific cysteine residues is required for tracking or analyzing molecular interactions.
| Molecular weight | 481.50 |
|---|---|
| Empirical formula | C28H23N3O5 |
| Assay | ≥50% (HPLC)≥97% (isomer purity, HPLC) |
| Solubility | DMSO: solublemethanol: soluble |
| Storage temperature | −20°C |
| Suitability | suitable for fluorescence |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 543 nm; λem 575 nm in 0.1 M phosphate pH 7.5 |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tetramethylrhodamine-6-maleimide used for?
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Tetramethylrhodamine-6-maleimide is primarily used for the fluorescent labeling of sulfhydryl groups (thiols) in biomolecules, particularly proteins, aiding in visualization and analysis in molecular biology and biochemical research.
What is the CAS number and formula for Tetramethylrhodamine-6-maleimide?
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The CAS number is 174568-68-4 and the empirical formula is C28H23N3O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tetramethylrhodamine-6-maleimide with an assay of ≥50% (HPLC) and ≥97% isomer purity (HPLC). This product is suitable for fluorescence applications and is not represented as USP, BP, or EP grade.
What are the safety precautions for handling Tetramethylrhodamine-6-maleimide?
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This compound is classified with GHS07 and a Warning signal word. It has hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Recommended personal protective equipment includes a dust mask (type N95), eyeshields, and gloves. Handle in a well-ventilated area and avoid inhalation, ingestion, and contact with skin and eyes.
How is Tetramethylrhodamine-6-maleimide packed and shipped?
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Tetramethylrhodamine-6-maleimide is typically stored at -20°C. TSS handles the export of chemicals globally, ensuring appropriate packaging and documentation for international shipment according to regulations.
How can I request a sample or quote for Tetramethylrhodamine-6-maleimide?
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To request a sample or a quotation for Tetramethylrhodamine-6-maleimide, please contact our sales department via the website or directly by email or phone, providing your specific requirements.
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