SIB 1893
SIB 1893 (CAS: 7370-21-0), a pyridine derivative with the molecular formula C14H13N and a molecular weight of 195.26 g/mol, is a valuable research chemical. This compound is primarily utilised for its role as a selective antagonist of metabotropic glutamate receptor 5 (mGluR5). Its application is crucial in studies investigating mGluR5-mediated cell signalling pathways, particularly within neuroscience and cell biology research.
- IUPAC
- [E]-2-Methyl-6-[2-phenylethenyl]pyridine
Neuroscience Research
SIB 1893 serves as a selective antagonist for mGluR5, making it instrumental in studies exploring the role of this receptor in neurotransmission and neurological processes. It aids in understanding the function of metabotropic glutamate receptors in brain function.
Cell Signaling Studies
This compound is employed to investigate mGluR5-mediated cell signalling pathways. Researchers utilise SIB 1893 to dissect the molecular mechanisms downstream of mGluR5 activation, contributing to the broader understanding of cellular communication.
GPCR Modulator Research
As a modulator of GPCRs, specifically mGluR5, SIB 1893 is used in research focused on G protein-coupled receptor functions and their therapeutic implications. Its selectivity aids in characterising specific receptor actions.
| Molecular weight | 195.26 |
|---|---|
| Empirical formula | C14H13N |
| Assay | >99% |
| Form | solid |
| Solubility | DMSO: soluble18 mg/mL |
| Storage temperature | 2-8°C |
| Application | SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... GRM1(2911), GRM5(2915) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SIB 1893 used for?
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SIB 1893 is primarily used as a selective antagonist of metabotropic glutamate receptor 5 (mGluR5) in research concerning mGluR5-mediated cell signalling, neuroscience, and cell biology.
What is the CAS number and chemical formula for SIB 1893?
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The CAS number for SIB 1893 is 7370-21-0, and its chemical formula is C14H13N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies SIB 1893 with an assay of >99%. This product is intended for research purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should SIB 1893 be handled safely?
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SIB 1893 is classified as a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). When handling, it is essential to wear appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
Is SIB 1893 a controlled substance?
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The provided data does not indicate that SIB 1893 is a controlled substance.
How is SIB 1893 packaged and shipped?
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SIB 1893 is supplied as a solid and should be stored at 2-8°C. Tech Serve Solutions exports fine chemicals globally, adhering to all necessary shipping and handling regulations for chemical compounds.
How can I request a quote or sample of SIB 1893?
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To request a quote or sample for SIB 1893, please contact our sales department through the website or via direct inquiry, providing your contact details and desired quantity.
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