N-Boc-piperidine-4-carbonitrile
N-Boc-piperidine-4-carbonitrile (CAS 91419-52-2, C11H18N2O2) is a heterocyclic building block with a molecular weight of 210.27. This compound serves as a key reactant in the synthesis of various complex organic molecules. Its applications span the creation of aminomethylated fluoropiperidines, protein kinase B inhibitors, and GlyT1 inhibitors, making it valuable in pharmaceutical research and development.
- IUPAC
- 1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate,1-Boc-4-cyanopiperidine,4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
- Synonyms
- 1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate1-Boc-4-cyanopiperidine4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
Synthesis of Aminomethylated Fluoropiperidines
N-Boc-piperidine-4-carbonitrile is utilized as a precursor in the synthesis of aminomethylated fluoropiperidine derivatives, which are of interest in medicinal chemistry.
Development of Protein Kinase B Inhibitors
This compound acts as a reactant in the multi-step synthesis of protein kinase B inhibitors, contributing to the development of potential therapeutic agents.
Preparation of GlyT1 Inhibitors
It serves as a building block for the creation of GlyT1 inhibitors, compounds investigated for their neurological applications.
Enantioselective Synthesis of Piperidinecarboxylic Acids
The nitrile group can undergo nitrilase-catalyzed transformations, enabling the enantioselective synthesis of valuable piperidinecarboxylic acid derivatives.
Modification of CB2 Receptor Inhibitors
N-Boc-piperidine-4-carbonitrile can be employed for structural modifications within CB2 receptor inhibitors, aiding in the exploration of structure-activity relationships.
| Molecular weight | 210.27 |
|---|---|
| Empirical formula | C11H18N2O2 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Application | Reactant for synthesis of:• Aminomethylated fluoropiperidines1• Protein kinase B inhibitors2• GlyT1 inhibitors3• Piperidinecarboxylic acids via nitrilase-catalyzed enantioselective synthesis4Reactant for• Replacement in CB2 receptor inhibitors5• Double addition reactions of methyllithium and n-butyllithium to unsaturated nitriles6 |
| Melting point | 60-63 °C |
Hazard statements
- H302Harmful if swallowed
- H319Causes serious eye irritation
- H400Very toxic to aquatic life
Precautionary statements
- P273Avoid release to the environment
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-36-50 |
| Safety statements (S) | 26-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Boc-piperidine-4-carbonitrile used for?
+
N-Boc-piperidine-4-carbonitrile is used as a reactant in the synthesis of various compounds, including aminomethylated fluoropiperidines, protein kinase B inhibitors, and GlyT1 inhibitors. It is also employed in the enantioselective synthesis of piperidinecarboxylic acids and for modifications in CB2 receptor inhibitors.
What are the CAS number and formula for N-Boc-piperidine-4-carbonitrile?
+
The CAS number for N-Boc-piperidine-4-carbonitrile is 91419-52-2, and its empirical formula (Hill notation) is C11H18N2O2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies N-Boc-piperidine-4-carbonitrile with a minimum assay of 97%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or any other pharmacopoeial grade.
How should N-Boc-piperidine-4-carbonitrile be handled?
+
N-Boc-piperidine-4-carbonitrile is classified as harmful if swallowed, causes serious eye irritation, and is very toxic to aquatic life. It requires appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure it is not released into the environment.
How is this chemical shipped and exported?
+
N-Boc-piperidine-4-carbonitrile is shipped and exported according to relevant transport regulations, identified as UN 3077, Class 9, Packing Group III, due to its environmental hazards. Tech Serve Solutions adheres to all international shipping and export requirements.
How can I request a quote or sample?
+
To request a quote or a sample of N-Boc-piperidine-4-carbonitrile, please use the contact form on our website or contact our sales department directly. Our team will be pleased to assist you with your inquiry.
▶ Related products
4-Amino-2-chloropyridine
C5H5ClN2
Heterocyclic Building Blocks
4-Ethynyl-1-methyl-1H-pyrazole
C6H6N2
Heterocyclic Building Blocks
4-Hydroxyquinoline-3-carboxylic acid ethyl ester
C12H11NO3
Heterocyclic Building Blocks
4-isocyanatopyridine
C6H4N2O
Heterocyclic Building Blocks
5-Chloro-2,8-dimethylquinoline
Heterocyclic Building Blocks
5-Chloro-2-methylene-1,3,3-trimethylindoline
Heterocyclic Building Blocks
5-Chloro-2-thiophenecarbonitrile
Heterocyclic Building Blocks
5-ethynyl-1H-pyrazole
C5H4N2
Heterocyclic Building Blocks▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis