N-Boc-4-piperidineacetaldehyde
N-Boc-4-piperidineacetaldehyde (CAS: 142374-19-4), with the molecular formula C12H21NO3 and a molar mass of 227.30 g/mol, is a key organic building block. This compound serves as a versatile intermediate in complex chemical syntheses, particularly in the development of novel pharmaceutical agents and specialised organic molecules. Its aldehyde functionality, protected by the N-Boc group on the piperidine ring, allows for selective reactions critical in multi-step synthetic pathways.
- IUPAC
- 4-(2-Oxoethyl)piperidine-1-carboxylic acid, tert-butyl ester,tert-Butyl 4-(formylmethyl)piperidine-1-carboxylate
- Synonyms
- tert-Butyl 4-(formylmethyl)piperidine-1-carboxylate
Synthesis of Quinuclidine Derivatives
This building block is employed in the synthesis of (S)-quinuclidine-2-carboxylic acid, a compound with potential applications in medicinal chemistry. The structure allows for the precise introduction of the quinuclidine core into more complex molecular frameworks.
Organo-Catalytic Vinylation Reactions
N-Boc-4-piperidineacetaldehyde serves as a substrate in enantioselective organo-catalytic α-vinylation reactions. This application highlights its utility in asymmetric synthesis, enabling the creation of chiral molecules with high stereoselectivity.
Heterocyclic Chemistry
As a functionalised piperidine derivative, it is valuable in heterocyclic building block synthesis. Its structure is amenable to further modifications, facilitating access to a range of nitrogen-containing heterocyclic compounds.
| Molecular weight | 227.30 |
|---|---|
| Empirical formula | C12H21NO3 |
| Assay | 97% |
| Application | Building block employed in a synthesis of (S)-quinuclidine-2-carboxylic acid.7 Substrate used in an enanioselective organo-catalytic α-vinylation reaction.8 |
| Melting point | 38-42 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Boc-4-piperidineacetaldehyde used for?
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N-Boc-4-piperidineacetaldehyde is primarily used as a building block in organic synthesis, including the synthesis of (S)-quinuclidine-2-carboxylic acid and in enantioselective organo-catalytic α-vinylation reactions.
What is the CAS number and formula for N-Boc-4-piperidineacetaldehyde?
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The CAS number is 142374-19-4, and the empirical formula is C12H21NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Boc-4-piperidineacetaldehyde with an assay of 97%. This product is intended for research and technical use and is not supplied as USP, BP, EP, or pharmacopoeia grade.
What are the safety considerations when handling N-Boc-4-piperidineacetaldehyde?
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This compound is classified with GHS07 and a 'Warning' signal word. It carries hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Recommended personal protective equipment includes a dust mask (N95), eyeshields, and gloves. Handle in a well-ventilated area and avoid dust formation.
Is N-Boc-4-piperidineacetaldehyde a controlled substance?
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The provided data does not indicate that N-Boc-4-piperidineacetaldehyde is a controlled substance.
How is N-Boc-4-piperidineacetaldehyde packed and exported?
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As a specialist global supplier, Tech Serve Solutions ensures appropriate packaging for the safe handling, storage, and export of N-Boc-4-piperidineacetaldehyde, adhering to international shipping regulations.
How can I request a quote or sample?
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To request a quote or a sample of N-Boc-4-piperidineacetaldehyde, please contact our sales team through the website or by phone, providing your specific requirements.
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