N-Acetyl-5-hydroxytryptamine
N-Acetyl-5-hydroxytryptamine (CAS 1210-83-9), also known as N-acetylserotonin or normelatonin, is an indoleamine of molecular formula C12H14N2O2 and molar mass 218.25 g/mol. It is the naturally occurring N-acetylated derivative of serotonin and the direct biosynthetic precursor of melatonin. Tech Serve Solutions supplies it as a high-purity research reagent and heterocyclic building block for use in neurochemistry, cell biology and synthetic chemistry applications.
- IUPAC
- N-Acetylserotonin,Normelatonin
- Synonyms
- N-AcetylserotoninNormelatoninN-Acetyl-5-hydroxytryptamine5-Hydroxy-N-acetyltryptamineN-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]acetamideNAS
Melatonin biosynthesis research
N-Acetylserotonin is the immediate precursor of melatonin, formed from serotonin by arylalkylamine N-acetyltransferase and converted to melatonin by acetylserotonin O-methyltransferase. It is widely used as a reference compound in studies of the indoleamine and circadian biosynthetic pathway.
Neurochemistry and cell biology
As a bioactive small molecule of the indole class, it serves as a tool compound in cell biology and neurochemical investigations. It is supplied for laboratory research use only.
Heterocyclic building block
The 5-hydroxyindole scaffold makes this compound a useful building block in chemical synthesis. It can act as a starting material or intermediate in the preparation of related indole and tryptamine derivatives.
Analytical reference standard
With a defined assay and melting point, it can be used as a characterised reference material for chromatographic and spectroscopic method development involving serotonin- and melatonin-related metabolites.
| Molecular weight | 218.25 |
|---|---|
| Empirical formula | C12H14N2O2 |
| Assay | 99% |
| Solubility | ethanol: soluble50 mg/mL |
| Storage temperature | 2-8°C |
| Melting point | 120-122 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Acetyl-5-hydroxytryptamine used for?
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It is used primarily as a research reagent and reference compound. As the direct precursor of melatonin in the indoleamine pathway, it supports neurochemistry, circadian and cell-biology research, and it also serves as a heterocyclic building block in chemical synthesis. It is supplied for laboratory research use only, not for therapeutic or diagnostic use.
What is the CAS number and molecular formula of N-Acetyl-5-hydroxytryptamine?
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The CAS number is 1210-83-9 and the molecular formula is C12H14N2O2, with a molecular weight of 218.25 g/mol. Its EC number is 214-916-5 and its MDL number is MFCD00005656. It is also known as N-acetylserotonin or normelatonin.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Acetyl-5-hydroxytryptamine at a typical assay of 99% as a research/reagent grade material. We do not represent it as USP, BP, EP or any pharmacopoeial grade unless a specific certificate is agreed in writing. A certificate of analysis can be provided with each batch on request.
How should N-Acetyl-5-hydroxytryptamine be stored and handled?
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Store the material refrigerated at 2-8°C in a tightly closed container, protected from light and moisture. Handle in line with good laboratory practice using suitable personal protective equipment, including eye protection (eyeshields), gloves and an N95 (US) or P1 (EN143) respirator filter where dust may be generated. It is classified WGK 3 in Germany (severely hazardous to water), so prevent release into drains, soil or watercourses and dispose of waste in accordance with local regulations. Always refer to the current Safety Data Sheet before use.
How is N-Acetyl-5-hydroxytryptamine packed, shipped and exported?
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It is packed in appropriate laboratory and bulk containers sized to the order, sealed and labelled, and typically shipped cold under refrigerated (2-8°C) conditions to preserve quality. Tech Serve Solutions exports worldwide with full documentation, including a certificate of analysis and Safety Data Sheet, and can accommodate customer-specific packing and labelling requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with the product name, CAS number 1210-83-9, the quantity and grade you require, and your destination country. We will confirm availability, lead time, packing and export terms, and provide a formal quotation.
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