N-(5-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide
N-(5-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide (CAS 873302-38-6; C10H13IN2O; molar mass 304.13 g/mol) is a halogenated pyridine building block. It pairs a reactive 3-iodopyridine site with a robust pivaloyl (2,2-dimethylpropionamide) group on the adjacent amine. The aryl iodide is a versatile handle for transition-metal cross-coupling, making this a useful intermediate in pharmaceutical and fine-chemical synthesis. Tech Serve Solutions supplies it worldwide as a research-grade heterocyclic building block.
- Synonyms
- N-(5-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamideN-(5-Iodopyridin-3-yl)pivalamideN-(5-Iodo-3-pyridinyl)-2,2-dimethylpropanamide2,2-Dimethyl-N-(5-iodopyridin-3-yl)propanamideCAS 873302-38-6C10H13IN2O
Cross-coupling building block
The aryl iodide serves as a reactive site for palladium- and nickel-catalysed cross-coupling reactions such as Suzuki-Miyaura, Sonogashira, Negishi and Stille couplings, allowing controlled carbon-carbon bond formation on the pyridine ring.
Pharmaceutical intermediate
As a functionalised pyridine scaffold, it is used in medicinal-chemistry programmes and discovery synthesis to elaborate substituted aminopyridine cores toward drug candidates and lead compounds.
Buchwald-Hartwig amination substrate
The carbon-iodine bond is well suited to palladium-catalysed C-N coupling, enabling the introduction of amine substituents and the construction of more complex nitrogen-containing heterocycles.
Protected aminopyridine handle
The 2,2-dimethylpropionamide (pivalamide) acts as a stable protecting and directing group for the pyridin-3-amine, supporting selective downstream functionalisation that can later be revealed by amide hydrolysis.
Laboratory research reagent
It is employed as a reference building block in methodology development and route-scouting work where a defined iodo-substituted pyridine is required.
| Molecular weight | 304.13 |
|---|---|
| Empirical formula | C10H13IN2O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(5-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide used for?
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It is used mainly as a building block in chemical synthesis. The reactive aryl iodide makes it a convenient substrate for transition-metal cross-coupling (Suzuki, Sonogashira, Negishi and Buchwald-Hartwig reactions), while the pivalamide group protects and directs the adjacent pyridine amine, supporting the assembly of more complex pyridine-based molecules and pharmaceutical intermediates.
What is the CAS number and molecular formula of N-(5-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide?
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Its CAS number is 873302-38-6 and its empirical formula is C10H13IN2O (Hill notation), corresponding to a molecular weight of 304.13 g/mol. It belongs to the halogenated heterocycle and pyridine building-block family.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research / technical-grade heterocyclic building block. Assay and exact specifications are confirmed on the certificate of analysis for each batch. We do not represent it as USP, BP or EP pharmacopoeial grade; if you require a specific assay or additional analytical data, please state this when requesting a quote.
How should N-(5-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide be handled and stored?
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Handle it as a laboratory research chemical: use appropriate personal protective equipment, work in a well-ventilated area or fume hood, and avoid contact with skin, eyes and inhalation of dust. Store in a tightly closed container in a cool, dry place away from incompatible materials. Always refer to the current Safety Data Sheet, supplied with the product, for the definitive GHS classification and handling guidance.
How is N-(5-Iodo-pyridin-3-yl)-2,2-dimethyl-propionamide packed, shipped and exported?
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It is packed in suitable laboratory and bulk containers with full labelling and accompanying documentation, and exported worldwide. Packaging and transport are arranged in line with applicable dangerous-goods and country-specific import requirements; we can provide the Safety Data Sheet and certificate of analysis to support customs clearance.
How do I request a sample or quote?
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Contact Tech Serve Solutions with the product name or CAS number 873302-38-6, your required quantity and destination country. We will confirm availability, specifications and lead time, and can arrange a sample or formal quotation for research and commercial volumes.
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