N-(2-Chloro-6-((trimethylsilyl)ethynyl)pyridin-3-yl)pivalamide
N-(2-Chloro-6-((trimethylsilyl)ethynyl)pyridin-3-yl)pivalamide (CAS 1142191-97-6) is a multifunctional pyridine building block with the molecular formula C15H21ClN2OSi and a molar mass of 308.88 g/mol. It combines a chloropyridine ring, a pivalamide-protected amine and a trimethylsilyl-protected alkyne, making it a versatile intermediate for organic and medicinal chemistry synthesis. Tech Serve Solutions supplies it as a research-grade reagent for laboratory and process development use.
- Synonyms
- N-(2-Chloro-6-((trimethylsilyl)ethynyl)pyridin-3-yl)pivalamideN-[2-chloro-6-(2-trimethylsilylethynyl)pyridin-3-yl]-2,2-dimethylpropanamide2,2-dimethyl-N-(2-chloro-6-((trimethylsilyl)ethynyl)pyridin-3-yl)propanamideN-(2-chloro-6-((trimethylsilyl)ethynyl)pyridin-3-yl)-2,2-dimethylpropanamideCAS 1142191-97-6
Heterocyclic building block
Serves as a halogenated pyridine scaffold for constructing more complex nitrogen heterocycles. The assembled chloride, alkyne and protected-amine functions allow sequential, selective elaboration during multi-step synthesis.
Cross-coupling intermediate
The 2-chloro substituent on the pyridine ring provides a handle for transition-metal-catalysed cross-coupling reactions such as Suzuki, Negishi and Buchwald-Hartwig amination, enabling further carbon-carbon and carbon-nitrogen bond formation.
Terminal alkyne precursor
The trimethylsilyl (TMS) group protects the ethynyl function and can be removed under mild basic or fluoride conditions to reveal a terminal alkyne, which is widely used in Sonogashira coupling and click (CuAAC) chemistry.
Protected aminopyridine reagent
The pivalamide masks the 3-amino group as a robust, sterically hindered amide that tolerates many reaction conditions and directs metalation, then can be hydrolysed to regenerate the free amine when required.
Pharmaceutical and agrochemical research
As an organosilicon-functionalised pyridine, it is suited to discovery and route-development programmes that prepare pyridine-containing candidate molecules. Specific end-use should be confirmed by the customer for their application.
| Molecular weight | 308.88 |
|---|---|
| Empirical formula | C15H21ClN2OSi |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(2-Chloro-6-((trimethylsilyl)ethynyl)pyridin-3-yl)pivalamide used for?
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It is used primarily as a building block and intermediate in organic and medicinal chemistry. Its chloropyridine ring, TMS-protected alkyne and pivalamide-protected amine allow chemists to carry out cross-coupling, alkyne deprotection and selective functionalisation when building more complex pyridine-based molecules.
What is the CAS number and molecular formula of N-(2-Chloro-6-((trimethylsilyl)ethynyl)pyridin-3-yl)pivalamide?
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Its CAS number is 1142191-97-6 and its molecular formula is C15H21ClN2OSi, corresponding to a molecular weight of 308.88 g/mol.
What grade and purity does Tech Serve Solutions supply?
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We supply this compound as a research- and laboratory-grade reagent intended for synthesis. The verified data does not specify a fixed assay, so a current specification and certificate of analysis are provided with each batch on request. We do not represent it as a USP, BP or EP pharmacopoeial grade.
What safety and handling precautions apply?
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No GHS classification is included in the verified data supplied to us, so a formal hazard profile is not confirmed here. As with any research chemical of incomplete hazard data, handle it as potentially hazardous: work in a fume hood, wear gloves, eye protection and a lab coat, avoid dust, skin and eye contact, and keep it dry and sealed. Always consult our current Safety Data Sheet before use.
How is N-(2-Chloro-6-((trimethylsilyl)ethynyl)pyridin-3-yl)pivalamide packed, shipped and exported?
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It is packed in suitably sealed containers sized to the order, from gram quantities to larger research lots, with appropriate inner protection and labelling. As a specialist exporter since 1998, Tech Serve Solutions arranges compliant international documentation and shipping to laboratories and manufacturers worldwide.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, quoting CAS 1142191-97-6. We will respond with availability, lead time, specification details and a formal quotation, and can arrange a sample where appropriate.
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