Methyl p-toluenesulfonate
Methyl p-toluenesulfonate (CAS: 80-48-8), with the chemical formula CH3C6H4SO3CH3 and a molecular weight of 186.23 g/mol, is a key organic compound. This tosylate ester serves as a versatile building block in chemical synthesis. It is primarily utilised in organic chemistry research and development for the introduction of the tosyl group, facilitating various chemical transformations.
Organic Synthesis Reagent
Methyl p-toluenesulfonate is frequently employed as a tosylating agent in organic synthesis. It enables the conversion of alcohols and amines into their corresponding tosylates and tosylamides, respectively, which are excellent leaving groups for subsequent nucleophilic substitution reactions.
Pharmaceutical Intermediate
In the pharmaceutical industry, this compound can act as an intermediate in the synthesis of complex active pharmaceutical ingredients (APIs). Its reactivity allows for the construction of specific molecular architectures required for drug development.
Research and Development
As a readily available building block, Methyl p-toluenesulfonate is a valuable reagent for academic and industrial research laboratories exploring new synthetic pathways and novel chemical entities.
| Molecular weight | 186.23 |
|---|---|
| Linear formula | CH3C6H4SO3CH3 |
| Assay | 98% |
| Boiling point | 144-145 °C/5 mmHg(lit.) |
| Density | 1.234 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5172(lit.) |
| Vapour pressure | 1 mmHg (20 °C) |
| Melting point | 25-28 °C(lit.) |
| Vapour density | 6.45 (vs air) |
| Autoignition temp | 896 °F |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H317May cause an allergic skin reaction
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34-43 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl p-toluenesulfonate (CAS 80-48-8) used for?
+
Methyl p-toluenesulfonate (CAS: 80-48-8) is primarily used as a tosylating agent in organic synthesis and as a building block for creating more complex molecules, including potential pharmaceutical intermediates and in research and development settings.
What is the CAS number and chemical formula for Methyl p-toluenesulfonate?
+
The CAS number for Methyl p-toluenesulfonate is 80-48-8, and its chemical formula is CH3C6H4SO3CH3.
What grade and purity does Tech Serve Solutions supply for Methyl p-toluenesulfonate?
+
Tech Serve Solutions supplies Methyl p-toluenesulfonate with a minimum assay of 98%. This product is typically supplied as a technical or research grade, and TSS does not represent it as USP, BP, or EP grade unless explicitly stated.
How should Methyl p-toluenesulfonate be handled safely?
+
Methyl p-toluenesulfonate is classified as corrosive and a skin sensitiser. Handle with appropriate personal protective equipment, including eyeshields, faceshields, gloves, and respiratory protection (type N100 or P3 filters). Avoid contact with skin, eyes, and clothing. It is labelled with GHS05 and GHS07 symbols and the signal word 'Danger'.
How is Methyl p-toluenesulfonate packed, shipped, and exported?
+
Methyl p-toluenesulfonate is carefully packed to ensure safe transit and is available for global export by Tech Serve Solutions, adhering to all relevant shipping regulations for hazardous materials (UN 3261).
How can I request a sample or quote for Methyl p-toluenesulfonate?
+
To request a sample or a quote for Methyl p-toluenesulfonate, please contact our sales team through the website or by phone, providing your specific requirements and delivery details.
▶ Related products
3,4,5-Trimethoxybenzylamine
Organic Building Blocks
3,4-dihydroxyphenylacetone
Organic Building Blocks
3-Fluoro-4-methoxybenzonitrile
C8H6FNO
Organic Building Blocks
4-Ethyltoluene
C2H5C6H4CH3
Organic Building Blocks
Fluoroacetic acid
C2H3FO2
Organic Building Blocks
Methoxyacetaldehyde
C3H6O2
Organic Building Blocks
Methyl 4-acetamido-5-chloro-2-methoxybenzoate
Organic Building Blocks
Methyl 5-bromo-2-iodobenzoate
BrC6H3(I)CO2CH3
Organic Building Blocks
