Methyl indole-1-carboxylate
Methyl indole-1-carboxylate (CAS 39203-20-8) is an N-substituted indole building block with the molecular formula C10H9NO2 and a molar mass of 175.18 g/mol. The methoxycarbonyl group on the indole nitrogen makes it a useful intermediate in organic and medicinal chemistry. It serves as a reactant in the synthesis of complex heterocycles, in Friedel-Crafts alkylation of indoles and in oxidative free-radical reactions. Tech Serve Solutions supplies it as a research-grade reagent for laboratory and synthesis use.
- IUPAC
- N-(Methoxycarbonyl)indole,Indole-1-carboxylic acid methyl ester
- Synonyms
- Methyl indole-1-carboxylateN-(Methoxycarbonyl)indoleIndole-1-carboxylic acid methyl esterMethyl 1H-indole-1-carboxylate1-(Methoxycarbonyl)indole
Heterocyclic building block
Used as an N-protected indole scaffold for constructing more complex heterocyclic systems, including tetracyclic indolines, in multi-step organic synthesis.
Pharmaceutical intermediate synthesis
Documented as a reactant in the preparation of the Bcl inhibitor obatoclax, supporting medicinal-chemistry and pharmaceutical research programmes.
Friedel-Crafts alkylation of indoles
Functions as a substrate in Friedel-Crafts alkylation reactions of indoles, enabling regioselective carbon-carbon bond formation on the indole ring.
Oxidative free-radical chemistry
Serves as a reactant in oxidative free-radical reactions, providing access to functionalised indole derivatives for methodology development.
Laboratory reagent
Supplied as a research-grade reagent for general laboratory use where a defined N-(methoxycarbonyl)indole starting material is required.
| Molecular weight | 175.18 |
|---|---|
| Empirical formula | C10H9NO2 |
| Assay | 97% |
| Density | 1.191 g/mL at 25 °C |
| Refractive index | n20/D 1.583 |
| Application | • Reactant for preparation of Bcl Inhibitor Obatoclax1• Reactant for preparation of tetracyclic indolines2• Reactant for Friedel-Crafts alkylation reaction of indoles3• Reactant for oxidative free radical reactions4 |
Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >100 °C / >212 °F |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl indole-1-carboxylate used for?
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It is used as an N-substituted indole building block in organic and medicinal chemistry. Documented uses include the synthesis of the Bcl inhibitor obatoclax and tetracyclic indolines, Friedel-Crafts alkylation of indoles and oxidative free-radical reactions.
What is the CAS number and molecular formula of Methyl indole-1-carboxylate?
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The CAS number is 39203-20-8 and the molecular formula is C10H9NO2 (Hill notation), with a molecular weight of 175.18 g/mol and MDL number MFCD11656094.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl indole-1-carboxylate as a research-grade reagent with a typical assay of 97%. We do not represent it as USP, BP or EP pharmacopoeia grade. A Certificate of Analysis can be provided with each batch on request.
What are the safety and handling precautions for Methyl indole-1-carboxylate?
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It is classified under GHS with signal word Danger and pictograms GHS05 and GHS07. It is harmful if swallowed (H302) and causes serious eye damage (H318). Wear gloves, eye and face protection, avoid ingestion, and on eye contact rinse cautiously with water for several minutes (P305 + P351 + P338). Consult the Safety Data Sheet before use.
How is Methyl indole-1-carboxylate packed, shipped and exported?
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It is packed in appropriately sized, well-sealed containers with full labelling and a Safety Data Sheet. Packaging is selected to suit the order quantity and destination, and the product is shipped and exported worldwide in accordance with the applicable transport and customs requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time, documentation and a formal quotation. Samples can be arranged for qualified evaluation requirements.
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