1-Boc-4-(aminomethyl)piperidine
1-Boc-4-(aminomethyl)piperidine (CAS: 144222-22-0) is a heterocyclic organic compound with the molecular formula C11H22N2O2 and a molecular weight of 214.30 g/mol. It serves as a valuable building block in chemical synthesis, particularly in the preparation of diverse biologically active molecules. Its primary utility lies in its role as a precursor for potential therapeutic agents, including protein agonists, antagonists, and enzyme inhibitors.
- IUPAC
- 1,1-Dimethylethyl 4-(aminomethyl)-1-piperidinecarboxylate,N-(tert-Butoxycarbonyl)-4-aminomethylpiperidine
Precursor for Protein Modulators
This compound is employed as a precursor in the synthesis of various protein agonists and antagonists. These derivatives have shown potential in diverse therapeutic areas, including anticancer and antidiabetic applications.
Synthesis of Enzyme Inhibitors
It acts as a key intermediate in the preparation of inhibitors for enzymes such as Kinesin spindle protein and Pim-1. These inhibitors are investigated for their potential in treating diseases like cancer.
Intermediate in Aziridine Synthesis
1-Boc-4-(aminomethyl)piperidine is utilised as a reactant in the enantioselective synthesis of N-alkyl terminal aziridines, which are important intermediates in organic chemistry.
| Molecular weight | 214.30 |
|---|---|
| Empirical formula | C11H22N2O2 |
| Assay | 97% |
| Boiling point | 237-238 °C(lit.) |
| Density | 1.013 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.473(lit.) |
| Application | Precursor in the preparation of a variety of different protein agonists or antagonists including:• Kinesin spindle protein inhibitors with potential anticancer activity1• Orphan G-protein coupled receptor GPR119 agonist with antidiabetic potential2• Pim-1 inhibitors3• Aspartic acid protease inhibitors4Reactant involved in enantioselective synthesis of N-alkyl terminal aziridines5 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 3082 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi,N |
| Risk statements (R) | 36/37/38-50 |
| Safety statements (S) | 26-36-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Boc-4-(aminomethyl)piperidine used for?
+
1-Boc-4-(aminomethyl)piperidine is primarily used as a building block and precursor in organic synthesis, particularly for preparing potential therapeutic agents like protein agonists/antagonists and enzyme inhibitors, as well as in the synthesis of N-alkyl terminal aziridines.
What are the CAS number and molecular formula for 1-Boc-4-(aminomethyl)piperidine?
+
The CAS number is 144222-22-0 and the molecular formula is C11H22N2O2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 1-Boc-4-(aminomethyl)piperidine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 1-Boc-4-(aminomethyl)piperidine be handled safely?
+
1-Boc-4-(aminomethyl)piperidine is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335), and is very toxic to aquatic life (H400). Handle with appropriate personal protective equipment, including eyeshields and gloves, and ensure adequate ventilation. Avoid release to the environment.
Is 1-Boc-4-(aminomethyl)piperidine a controlled substance?
+
The provided data does not indicate that 1-Boc-4-(aminomethyl)piperidine is a controlled substance.
How is this chemical packed and exported by TSS?
+
As a global supplier and exporter, Tech Serve Solutions ensures appropriate packaging for international shipment of 1-Boc-4-(aminomethyl)piperidine, adhering to all relevant transport regulations, including UN 3082 for environmentally hazardous substances.
How can I request a quote or sample?
+
Please contact our sales team via the website or direct email to request a quote or a sample of 1-Boc-4-(aminomethyl)piperidine.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
