Tris(2-carboxyethyl)phosphine hydrochloride
Tris(2-carboxyethyl)phosphine hydrochloride (CAS 51805-45-9), with the molecular formula C9H15O6P · HCl, is a highly effective, water-soluble reducing agent. It is favoured for its stability and utility in mass spectrometry applications, offering selective reduction of disulfides. This compound is a valuable reagent in chemical synthesis and various laboratory procedures, ensuring reliable experimental outcomes.
- IUPAC
- TCEP
Selective Disulfide Reduction
This compound serves as a water-soluble reagent for the selective reduction of disulfide bonds. Its efficacy makes it a preferred choice over DTT in many biochemical applications.
Mass Spectrometry Applications
Due to its superior stability and solubility, Tris(2-carboxyethyl)phosphine hydrochloride is particularly useful in mass spectrometry workflows. It aids in sample preparation by reducing disulfide linkages without interfering with downstream analysis.
Chemical Synthesis
As a versatile synthetic reagent, it facilitates various chemical transformations where controlled reduction is required. Its properties lend themselves to precise manipulations in organic synthesis.
SDS-PAGE Testing
This reagent has been tested for suitability in SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis), indicating its reliability for protein sample preparation and analysis.
| Molecular weight | 286.65 |
|---|---|
| Empirical formula | C9H15O6P · HCl |
| Assay | ≥98.0% (C) |
| Grade | purum |
| Density | 1.041 g/mL at 25 °C |
| Refractive index | n20/D 1.367 |
| pH | 7.0(aqueous solution; pH was adjusted with ammonium hydroxide) |
| Concentration | 0.5 M |
| Storage temperature | 2-8°C |
| Impurities tested | ≤0.5% water |
| Application | Water soluble reagent, used for selective reduction of disulfides.1 More stable than DTT and useful in mass spectrometry applications. |
| Suitability | SDS-PAGE tested |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tris(2-carboxyethyl)phosphine hydrochloride used for?
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Tris(2-carboxyethyl)phosphine hydrochloride is primarily used as a water-soluble reagent for the selective reduction of disulfide bonds, with particular utility in mass spectrometry applications and chemical synthesis. It is also tested for suitability in SDS-PAGE.
What are the CAS number and formula for Tris(2-carboxyethyl)phosphine hydrochloride?
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The CAS number is 51805-45-9 and the empirical formula is C9H15O6P · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tris(2-carboxyethyl)phosphine hydrochloride with a purity of ≥98.0% (C) and a grade of Purum. We do not represent this product as USP, BP, or EP grade.
What are the safety precautions for handling Tris(2-carboxyethyl)phosphine hydrochloride?
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This compound is classified as Danger, with hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection, must be used. Handle with care in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive guidance.
Is Tris(2-carboxyethyl)phosphine hydrochloride packed and exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Tris(2-carboxyethyl)phosphine hydrochloride, packed and shipped according to international regulations.
How can I request a sample or quote for Tris(2-carboxyethyl)phosphine hydrochloride?
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To request a sample or a quotation for Tris(2-carboxyethyl)phosphine hydrochloride, please contact our sales team through the website or via direct inquiry.
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