Tris(2,2,2-trifluoroethyl) phosphite
Tris(2,2,2-trifluoroethyl) phosphite (CAS: 370-69-4) is a fluorinated organophosphorus compound with a molecular weight of 328.07 g/mol. It serves as a valuable building block in organic synthesis, particularly for introducing trifluoroethoxy groups. This chemical is primarily used in research and development settings for the synthesis of novel compounds, including specialized phosphonamides, contributing to advancements in chemical synthesis.
- Synonyms
- 370-69-4(CF3CH2O)3P
Organic Synthesis Intermediate
Tris(2,2,2-trifluoroethyl) phosphite is utilised as a key intermediate in the synthesis of complex organic molecules. It facilitates the introduction of trifluoroethoxy functionalities, which can impart unique electronic and physical properties to target compounds.
Phosphonamide Synthesis
This phosphite derivative has been employed in the Arbuzov reaction for the synthesis of N-methoxy-N-methyl bis(2,2,2-trifluoroethyl)phosphonamide. This specific application highlights its utility in constructing specialized phosphorus-containing amides.
Research and Development
As a building block, Tris(2,2,2-trifluoroethyl) phosphite is instrumental in academic and industrial research laboratories for exploring new chemical pathways and developing novel materials or active pharmaceutical ingredients.
| Molecular weight | 328.07 |
|---|---|
| Linear formula | (CF3CH2O)3P |
| Assay | 99% |
| Boiling point | 130-131 °C/743 mmHg(lit.) |
| Density | 1.487 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.324(lit.) |
| Application | Tris(2,2,2-trifluoroethyl) phosphite was used in the synthesis of N-methoxy-N-methyl bis(2,2,2-trifluoroethyl)phosphonamide via the Arbuzov reaction with 2-bromo-N-methoxy-N-methylacetamide1. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tris(2,2,2-trifluoroethyl) phosphite used for?
+
Tris(2,2,2-trifluoroethyl) phosphite is primarily used as a building block in organic synthesis, for example, in the preparation of N-methoxy-N-methyl bis(2,2,2-trifluoroethyl)phosphonamide via the Arbuzov reaction.
What are the CAS number and chemical formula for Tris(2,2,2-trifluoroethyl) phosphite?
+
The CAS number is 370-69-4 and the linear formula is (CF3CH2O)3P.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Tris(2,2,2-trifluoroethyl) phosphite with an assay of 99%. This is a technical/research grade product, and TSS does not represent it as USP, BP, or EP grade.
How should Tris(2,2,2-trifluoroethyl) phosphite be handled safely?
+
Tris(2,2,2-trifluoroethyl) phosphite is classified as a Warning substance (GHS07) and causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, should be used. Ensure adequate ventilation.
Is Tris(2,2,2-trifluoroethyl) phosphite available for export?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Tris(2,2,2-trifluoroethyl) phosphite.
How can I request a quote or sample?
+
Please contact our sales team directly through our website or by phone to request a quote or sample of Tris(2,2,2-trifluoroethyl) phosphite.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis