Tris(2,2,2-trifluoroethyl) borate

CAS 659-18-7C6H6BF9O3Chemical Synthesis

Tris(2,2,2-trifluoroethyl) borate (CAS 659-18-7) is an organoborate compound with the molecular formula C6H6BF9O3 and a molecular weight of 307.91 g/mol. This reagent is primarily utilised in chemical synthesis, particularly for promoting the direct formation of amides from carboxylic acids and amines under thermal and microwave conditions. It is supplied by TSS with an assay of 98%.

IUPAC: Sheppard Amidation Reagent,Sheppard Reagent,Tris(2,2,2-trifluoroethoxy)boron,Tris(2,2,2-trifluoroethyl)borate
Synonyms: 659-18-7C6H6BF9O3Sheppard Amidation ReagentSheppard ReagentTris(2,2,2-trifluoroethoxy)boron

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Tris(2,2,2-trifluoroethyl) borate (C6H6BF9O3) — chemical structure, CAS 659-18-7; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisOrganoboratesOrganometallic Reagents

01 /Applications

Amide Synthesis

Tris(2,2,2-trifluoroethyl) borate acts as an effective reagent for the direct amidation of carboxylic acids with amines. This process can be accelerated using thermal or microwave irradiation.

Organoborate Chemistry

As a derivative within organoborate chemistry, this compound serves as a valuable building block or reagent in various synthetic pathways. Its trifluoroethyl groups influence its reactivity and properties.

Chemical Synthesis Reagent

This compound is employed as a specialised reagent in broader chemical synthesis applications, contributing to the development of new molecules and materials.

02 /Properties

Molecular weight	307.91
Empirical formula	C6H6BF9O3
Assay	98%
Density	1.430 g/mL at 25 °C
Refractive index	n/D 1.298(lit.)
Application	Reagent can promote the direct formation of amides from carboxylic acids and amines under thermal and microwave conditions.

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

Warning

Hazard statements

H226Flammable liquid and vapour

Flash point	43 °C / 109.4 °F
Transport (UN / ADR)	UN 1993C 3 / PGIII
Water hazard class (WGK, DE)	3
Risk statements (R)	10

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

659-18-7

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Tris(2,2,2-trifluoroethyl) borate used for?

Tris(2,2,2-trifluoroethyl) borate is primarily used as a reagent to promote the direct formation of amides from carboxylic acids and amines, often under thermal or microwave conditions.

What is the CAS number and formula for Tris(2,2,2-trifluoroethyl) borate?

The CAS number for Tris(2,2,2-trifluoroethyl) borate is 659-18-7, and its empirical formula (Hill notation) is C6H6BF9O3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tris(2,2,2-trifluoroethyl) borate with an assay of 98%. This is a technical/research grade chemical, and TSS does not represent it as USP, BP, or EP grade.

How should Tris(2,2,2-trifluoroethyl) borate be handled safely?

Tris(2,2,2-trifluoroethyl) borate is a flammable liquid and vapour (H226). Handle it in a well-ventilated area away from ignition sources. Refer to the Safety Data Sheet for comprehensive handling and safety information.

How is Tris(2,2,2-trifluoroethyl) borate packed and shipped?

Tris(2,2,2-trifluoroethyl) borate is packed and shipped according to international regulations for hazardous materials. As a specialist global supplier, TSS ensures compliance for export.