Triparanol
Triparanol (CAS 78-41-1), with the molecular formula C27H32NO2Cl and a molecular weight of 438.00, is a white to off-white powder. This compound serves as a potent inhibitor of cholesterol biosynthesis, particularly within lipid rafts. It is also recognised as a 3β-hydroxysteroid-Δ24-reductase inhibitor, making it valuable for research into its effects on biological processes, including delayed-rectifier potassium current (I<sub>ks</sub>) channels.
- IUPAC
- 1-(4-(2-Diethylaminoethoxy)phenyl)-1-p-tolyl-2-(4-chlorophenyl)ethanol
Cholesterol Biosynthesis Inhibition
Triparanol is utilized to investigate the mechanisms of cholesterol biosynthesis inhibition within cellular lipid rafts. This application is crucial for understanding lipid metabolism and its role in cellular function.
Enzyme Inhibition Studies
As a 3β-hydroxysteroid-Δ24-reductase inhibitor, Triparanol aids in research focused on sterol metabolism. It is employed to study the enzyme's function and its impact on biological pathways, such as ion channel activity.
Potassium Channel Research
The compound has been used to study the effects of enzyme inhibition on delayed-rectifier potassium current (I<sub>ks</sub>) channels. This research contributes to the understanding of ion transport and cardiac electrophysiology.
| Molecular weight | 438.00 |
|---|---|
| Empirical formula | C27H32NO2Cl |
| Assay | ≥97% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | DMSO: soluble20 mg/mLH2O: insolublealcohol: solubleolive oil: slightly soluble |
| Storage temperature | 2-8°C |
| Melting point | 102.9-103.7 °C |
| Application | Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts1. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (Iks) channels2. |
Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... EBP(10682) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Triparanol used for?
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Triparanol is used to inhibit cholesterol biosynthesis in lipid rafts and as a 3β-hydroxysteroid-Δ24-reductase inhibitor to study its effects on delayed-rectifier potassium current (I<sub>ks</sub>) channels.
What is the CAS number and formula for Triparanol?
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The CAS number for Triparanol is 78-41-1 and its empirical formula is C27H32NO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Triparanol with a purity of ≥97% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Triparanol be handled safely?
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Triparanol is classified as harmful if swallowed (H302) and causes serious eye damage (H318). Handling requires appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure good ventilation and avoid dust formation. In case of eye contact, rinse cautiously with water for several minutes.
How is Triparanol shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Triparanol is packed and shipped according to industry best practices and international regulations for chemical export.
How can I request a sample or quote for Triparanol?
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To request a sample or a quote for Triparanol, please contact our sales department through the TSS website or by phone.
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