Trimethylsilyl polyphosphate

CAS 40623-46-9{-P(=O)[OSi(CH3)3]O-}nAcids & Bases

Trimethylsilyl polyphosphate (CAS: 40623-46-9), with the linear formula {-P(=O)[OSi(CH3)3]O-}n, is a chemical reagent characterised by its refractive index of n20/D 1.434 and a density of 1.18 g/mL at 25 °C. Stored at 2-8 °C, it serves as a versatile dehydrating agent and is widely applied in organic synthesis, particularly in cyclisation and esterification reactions. Its acidic nature and compatibility with various organic solvents make it a valuable tool for synthetic chemists.

IUPAC: PPSE,Polyphosphoric acid trimethylsilyl ester
Synonyms: PPSEPolyphosphoric acid trimethylsilyl ester

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Trimethylsilyl polyphosphate ({-P(=O)[OSi(CH3)3]O-}n) — chemical structure, CAS 40623-46-9; Chemistry, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Organic Synthesis Reagent

Trimethylsilyl polyphosphate is frequently employed as a dehydrating agent and catalyst in various organic transformations. It facilitates reactions such as esterifications, cyclizations, and condensation reactions, offering an alternative to harsher reagents.

Dehydrating Agent

Its ability to effectively remove water makes it useful in reactions where water is a byproduct and needs to be sequestered to drive the equilibrium towards product formation. This is particularly valuable in sensitive organic syntheses.

Catalyst in Cyclisation Reactions

This compound can catalyse the formation of cyclic structures from linear precursors. Its efficacy in promoting intramolecular reactions is beneficial for the synthesis of heterocyclic compounds and complex organic molecules.

Esterification

Trimethylsilyl polyphosphate serves as an efficient reagent for the formation of esters from carboxylic acids and alcohols. It provides a mild yet effective method for ester synthesis in organic chemistry laboratories.

02 /Properties

Linear formula	{-P(=O)[OSi(CH3)3]O-}n
Density	1.18 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.434
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Danger

Hazard statements

H225Highly flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat, sparks and open flames. No smoking
P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	4 °C / 39.2 °F
Transport (UN / ADR)	UN 1993BF 3 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	F,Xi
Risk statements (R)	11-36/37/38
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

40623-46-9

MDL number

MFCD00148705

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Trimethylsilyl polyphosphate used for?

Trimethylsilyl polyphosphate (CAS: 40623-46-9) is primarily used as a dehydrating agent and catalyst in organic synthesis, particularly for esterification and cyclisation reactions.

What are the CAS number and formula for Trimethylsilyl polyphosphate?

The CAS number for Trimethylsilyl polyphosphate is 40623-46-9, and its linear formula is {-P(=O)[OSi(CH3)3]O-}n.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Trimethylsilyl polyphosphate typically for research and laboratory use. The specific assay and purity can be found on the product's Certificate of Analysis, and we do not represent this product as USP, BP, or EP grade.

What are the main safety hazards associated with Trimethylsilyl polyphosphate?

Trimethylsilyl polyphosphate is a flammable liquid and vapour (H225) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eye protection, gloves, and respiratory protection, must be used when handling this chemical.

How is Trimethylsilyl polyphosphate packed and shipped?

Tech Serve Solutions packs and ships Trimethylsilyl polyphosphate in compliance with all relevant transport regulations for hazardous materials. For export, it is handled according to international shipping standards for UN 1993, Class 3, Packing Group II flammable liquids.

How can I request a sample or quote for Trimethylsilyl polyphosphate?

To request a sample or a quote for Trimethylsilyl polyphosphate, please contact our sales team via the website or directly by phone. Please specify the quantity and your intended application.