Trifluoromethanesulfonic acid

CAS 1493-13-6CF3SO3HAcids & Bases

Trifluoromethanesulfonic acid (CAS 1493-13-6), with the formula CF3SO3H and a molecular weight of 150.08 g/mol, is a highly acidic and corrosive substance. It is a superacid, valued for its strong protonating ability and utility as a catalyst in various organic reactions. Its primary applications include serving as a potent deglycosylation agent and in chemical synthesis, particularly in electrophilic substitution reactions where a strong acid is required.

IUPAC: Triflic acid

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Trifluoromethanesulfonic acid (CF3SO3H) — chemical structure, CAS 1493-13-6; Chemistry, fine chemical supplied by Tech Serve Solutions

AcidsAcids & BasesChemical SynthesisOrganic AcidsSynthetic Reagents

01 /Applications

Deglycosylation Agent

Trifluoromethanesulfonic acid is recognised for its efficacy as a deglycosylation agent. This property makes it valuable in carbohydrate chemistry and related fields for the selective removal of glycosidic bonds.

Catalysis in Organic Synthesis

As a strong Brønsted acid, triflic acid acts as an effective catalyst in a wide range of organic transformations. It promotes reactions such as alkylations, acylations, and polymerisations where highly acidic conditions are beneficial.

Electrophilic Substitution Reactions

This superacid is employed to facilitate electrophilic substitution reactions. Its strong acidity allows for the activation of substrates, enabling reactions that might not proceed with weaker acids.

02 /Properties

Molecular weight	150.08
Linear formula	CF3SO3H
Assay	98%
Boiling point	162 °C(lit.)
Density	1.696 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.327(lit.)
Concentration	0.1 M CF3SO3H in acetic acid (0.1N)
Vapour pressure	8 mmHg (25 °C)
Vapour density	5.2 (vs air)
Application	Deglycosylation agent

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Danger

Hazard statements

H302Harmful if swallowed
H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Transport (UN / ADR)	UN 3265 8 / PGII
Water hazard class (WGK, DE)	2
Hazard codes (EU)	C
Risk statements (R)	21/22-35
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1493-13-6

MDL number

MFCD00007514

PubChem substance

24861529

Beilstein registry

1812100

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Trifluoromethanesulfonic acid primarily used for?

Trifluoromethanesulfonic acid is primarily used as a deglycosylation agent and as a strong acid catalyst in various organic synthesis applications, including electrophilic substitution reactions.

What is the CAS number and formula for Trifluoromethanesulfonic acid?

The CAS number is 1493-13-6 and the chemical formula is CF3SO3H.

What grade and purity does Tech Serve Solutions supply for Trifluoromethanesulfonic acid?

Tech Serve Solutions supplies Trifluoromethanesulfonic acid with an assay of 98%. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.

How should Trifluoromethanesulfonic acid be handled safely?

Trifluoromethanesulfonic acid is highly corrosive and harmful if swallowed or inhaled. Appropriate personal protective equipment, including chemical-resistant gloves, eye protection (goggles and face shield), and respiratory protection, must be used. Handle only in well-ventilated areas. Refer to the safety data sheet for comprehensive handling instructions.

Does TSS export Trifluoromethanesulfonic acid?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Trifluoromethanesulfonic acid.

How can I request a quote or sample for Trifluoromethanesulfonic acid?

To request a quote or a sample, please contact our sales team through the website or via direct inquiry, providing your contact details and the product CAS number (1493-13-6).