Trifluoromethanesulfonyl chloride
Trifluoromethanesulfonyl chloride (CAS: 421-83-0, CF3SO2Cl) is a highly reactive chemical reagent with a molecular weight of 168.52 g/mol. It functions as a potent trifluoromethylating agent, particularly in Ru(II) complex-catalyzed reactions involving aromatics and alkenes. Its volatility and corrosive nature necessitate careful handling. This compound is an essential building block in various synthetic organic chemistry applications, contributing to the development of novel materials and pharmaceuticals.
- IUPAC
- Triflyl chloride
- Synonyms
- Triflyl chloride
Trifluoromethylating Agent
Utilised as a trifluoromethylating agent in conjunction with Ru(II) complex catalysts. It is effective for the trifluoromethylation of aromatic compounds, enabling the introduction of the CF3 group into complex molecular structures.
Alkene Trifluoromethylation
This reagent is also employed for the trifluoromethylation of alkenes. This application is crucial in organic synthesis for modifying unsaturated systems and creating valuable fluorinated intermediates.
Synthetic Organic Chemistry
Serves as a key reagent in diverse synthetic pathways. Its reactivity allows for the efficient formation of trifluoromethyl-containing molecules, which are prevalent in pharmaceuticals and advanced materials.
| Molecular weight | 168.52 |
|---|---|
| Linear formula | CF3SO2Cl |
| Assay | ≥99% |
| Boiling point | 29-32 °C(lit.) |
| Density | 1.583 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.334(lit.) |
| Vapour pressure | 10.36 psi (20 °C) |
| Storage temperature | 2-8°C |
| Application | Ru(II) complex-catalyzed trifluoromethylating agent for aromatics1 and alkenes.2 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trifluoromethanesulfonyl chloride used for?
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Trifluoromethanesulfonyl chloride (CAS: 421-83-0) is primarily used as a trifluoromethylating agent, catalysed by Ru(II) complexes, for the synthesis of trifluoromethylated aromatics and alkenes.
What is the CAS number and chemical formula for Trifluoromethanesulfonyl chloride?
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The CAS number is 421-83-0, and the chemical formula is CF3SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trifluoromethanesulfonyl chloride with an assay of ≥99%. We do not represent this product as USP, BP, or EP grade.
How should Trifluoromethanesulfonyl chloride be handled safely?
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Trifluoromethanesulfonyl chloride is corrosive and reacts violently with water. Handle with extreme caution in a well-ventilated area, using appropriate personal protective equipment including face shields, gloves, and respirators. Refer to the Safety Data Sheet for detailed handling procedures.
How is Trifluoromethanesulfonyl chloride packed and shipped?
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Trifluoromethanesulfonyl chloride is packed and shipped in accordance with international regulations for hazardous materials, typically as UN 3265, Class 8, Packing Group II.
How can I request a sample or quote for Trifluoromethanesulfonyl chloride?
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To request a sample or quote, please contact the Tech Serve Solutions sales team via our website or directly through established contact channels.
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