Triethyl orthoformate
Triethyl orthoformate (CAS: 122-51-0), a clear, colourless liquid with the chemical formula CH(OC2H5)3, is a versatile organic compound. With a molecular weight of 148.20 g/mol, it serves as a crucial building block in organic synthesis. Its primary applications include acting as a dehydrating agent and a precursor in the synthesis of various organic molecules, particularly pharmaceuticals and heterocycles. It is supplied by TSS with an assay of 98%.
- IUPAC
- 1,1,1-Triethoxymethane
- Synonyms
- 1,1,1-Triethoxymethane
Organic Synthesis Reagent
Triethyl orthoformate is widely employed as a reagent in organic synthesis. It is particularly useful for the formylation of active methylene compounds and as a dehydrating agent in esterification and acetal formation reactions.
Pharmaceutical Intermediate
This compound serves as a key intermediate in the synthesis of various pharmaceutical agents. Its reactivity allows for the introduction of specific functional groups required in complex drug molecules.
Heterocyclic Chemistry
Triethyl orthoformate is valuable in the construction of heterocyclic ring systems. It can react with amines and other nucleophiles to form a variety of nitrogen-containing heterocycles.
Dehydrating Agent
Due to its ability to react with water, triethyl orthoformate is often used as an effective dehydrating agent in reactions where the removal of water is critical for driving the reaction forward or preventing side reactions.
| Molecular weight | 148.20 |
|---|---|
| Linear formula | CH(OC2H5)3 |
| Assay | 98% |
| Boiling point | 146 °C(lit.) |
| Density | 0.891 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.391(lit.) |
| Vapour pressure | 2.9 mmHg (20 °C) |
| Melting point | −76 °C(lit.) |
| Vapour density | 5.11 (vs air) |
Hazard statements
- H226Flammable liquid and vapour
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 35 °C / 95 °F |
| Transport (UN / ADR) | UN 2524 3 / PGIII |
| Water hazard class (WGK, DE) | 1 |
| Risk statements (R) | 10 |
| Safety statements (S) | 16-36/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Triethyl orthoformate used for?
+
Triethyl orthoformate is primarily used as a reagent in organic synthesis, a pharmaceutical intermediate, in heterocyclic chemistry, and as a dehydrating agent.
What are the CAS number and chemical formula for Triethyl orthoformate?
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The CAS number for Triethyl orthoformate is 122-51-0, and its chemical formula is CH(OC2H5)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Triethyl orthoformate with an assay of 98%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should Triethyl orthoformate be handled safely?
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Triethyl orthoformate is a flammable liquid and vapour (H226). Handle with care, ensuring adequate ventilation and avoiding ignition sources. It requires appropriate personal protective equipment, including eyeshields, gloves, and potentially a respirator.
Is Triethyl orthoformate flammable?
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Yes, Triethyl orthoformate is flammable, with a flash point of 35 °C (95 °F). It should be kept away from heat, sparks, and open flames.
How is Triethyl orthoformate packed and exported?
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Triethyl orthoformate is typically packed in compliance with relevant transport regulations for flammable liquids and exported globally by TSS.
How can I request a quote or sample for Triethyl orthoformate?
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Please contact the TSS sales team via our website or direct contact details to request a quote or sample of Triethyl orthoformate.
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