trans-Ferulic acid
Trans-Ferulic acid (CAS: 537-98-4) is a phenolic compound with the molecular formula C10H10O4 and a molecular weight of 194.18 g/mol. It functions as a potent antioxidant and free radical scavenger. This compound is utilised in chemical synthesis, cancer research, and various cell biology applications, including the development of biocompatible polymers and esterification reactions.
- IUPAC
- trans-4-Hydroxy-3-methoxycinnamic acid,Ferulic acid
- Synonyms
- 4-Hydroxy-3-methoxycinnamic acidFerulic acidtrans-4-Hydroxy-3-methoxycinnamic acid

Polymer Synthesis
Trans-Ferulic acid is employed in the synthesis of novel biocompatible antioxidant polymers. It can also be used for the esterification of methacrylated dextran, a process relevant in biomaterials research.
Biomedical Research
This compound has been studied for its potential effects on liver injury, specifically in models of ethanol-induced liver damage. Its antioxidant properties make it a subject of interest in cell biology and disease research.
Chemical Building Block
As a carboxylic acid with a functionalised aromatic ring, trans-Ferulic acid serves as a valuable building block in organic synthesis for creating more complex molecules.
| Molecular weight | 194.18 |
|---|---|
| Linear formula | HOC6H3(OCH3)CH=CHCO2H |
| Assay | 99% |
| Application | trans-Ferulic acid was used for esterification of methacrylated dextran1. It was also used to study the effect of oral administration of trans-ferulic acid to c57BL mice on ethanol-induced liver injury2. Furthermore, it has been used in the synthesis of new biocompatible antioxidant polymers linking trans-ferulic acid3. |
| Melting point | 168-172 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
| Cation traces | Ba: ≤5 mg/kgCa: ≤10 mg/kgCd: ≤5 mg/kgCo: ≤5 mg/kgCr: ≤5 mg/kgCu: ≤5 mg/kgFe: ≤20 mg/kgK: ≤50 mg/kgMg: ≤5 mg/kgMn: ≤5 mg/kgNa: ≤50 mg/kgNi: ≤5 mg/kgPb: ≤5 mg/kgZn: ≤5 mg/kg |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Absorption | absorption/337 nm ≥2000 (mol. absorption) |
|---|---|
| Analyte Suitability | peptidesproteins |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is trans-Ferulic acid used for?
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Trans-Ferulic acid is used in chemical synthesis, cancer research, cell biology applications, and in the development of biocompatible polymers and in esterification reactions. It is also studied for its antioxidant and free radical scavenging properties.
What is the CAS number and formula for trans-Ferulic acid?
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The CAS number for trans-Ferulic acid is 537-98-4, and its linear formula is HOC6H3(OCH3)CH=CHCO2H.
What grade and purity does Tech Serve Solutions supply for trans-Ferulic acid?
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Tech Serve Solutions supplies trans-Ferulic acid with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should trans-Ferulic acid be handled safely?
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Trans-Ferulic acid (CAS: 537-98-4) is classified with Warning signal word, with hazards H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure good ventilation.
Is trans-Ferulic acid available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including trans-Ferulic acid.
How can I request a quote or sample for trans-Ferulic acid?
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Please contact our sales team through the website to request a quote or sample for trans-Ferulic acid (CAS: 537-98-4).
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