tert-Butyl isocyanide
Tert-Butyl isocyanide (CAS: 7188-38-7) is an organic compound with the linear formula (CH3)3CNC and a molecular weight of 83.13 g/mol. This highly flammable liquid, with a purity of 98%, serves as a valuable building block in organic synthesis. Its applications include the creation of heterocyclic compounds like coumarines and isoxazolines, and it is also employed in trapping reactive intermediates.
Synthesis of Coumarines and Chromenes
Tert-Butyl isocyanide is utilised in the chemical synthesis of coumarines and 4H-chromenes, contributing to the formation of these important heterocyclic structures.
Formation of Isoxazolines
This isocyanide derivative is employed in the preparation of isoxazolines, a class of heterocyclic compounds with diverse applications in medicinal chemistry and materials science.
Trapping of Di-ones
Tert-Butyl isocyanide acts as a trapping agent for 2-cyclopropylidene-1,3-di-ones, facilitating the study and characterisation of these reactive intermediates.
| Molecular weight | 83.13 |
|---|---|
| Linear formula | (CH3)3CNC |
| Assay | 98% |
| Boiling point | 91 °C(lit.) |
| Density | 0.735 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.376(lit.) |
| Application | tert-Butyl isocyanide was used in the synthesis of coumarines, 4H-chromenes1 and isoxazolines2. It was also used to trap 2-cyclopropylidene-1,3-diones3. |
Hazard statements
- H225Highly flammable liquid and vapour
- H330Fatal if inhaled
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P284Wear respiratory protection
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -2 °C / 28.4 °F |
| Transport (UN / ADR) | UN 1993BE 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,T |
| Risk statements (R) | 11-23 |
| Safety statements (S) | 16-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tert-Butyl isocyanide used for?
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Tert-Butyl isocyanide is used as a building block in organic synthesis for preparing compounds such as coumarines, 4H-chromenes, and isoxazolines. It is also used to trap reactive intermediates like 2-cyclopropylidene-1,3-di-ones.
What are the CAS number and formula for Tert-Butyl isocyanide?
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The CAS number for Tert-Butyl isocyanide is 7188-38-7 and its linear formula is (CH3)3CNC.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tert-Butyl isocyanide with a minimum purity of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Tert-Butyl isocyanide be handled safely?
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Tert-Butyl isocyanide is highly flammable and toxic. Handle with extreme caution in a well-ventilated area or fume hood, wearing appropriate personal protective equipment including eyeshields, gloves, and a suitable respirator. Avoid ignition sources and ensure containment measures are in place.
How is this chemical shipped and exported?
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Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, including Tert-Butyl isocyanide, adhering to all necessary shipping and export regulations.
How can I request a sample or quote for Tert-Butyl isocyanide?
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To request a sample or a quote for Tert-Butyl isocyanide, please contact our sales team through the website or by phone.
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