tert-Butyl formate
Tert-Butyl formate (CAS: 762-75-4) is an organic compound with the linear formula HCOOC(CH3)3 and a molecular weight of 102.13 g/mol. This flammable ester, recognised for its characteristic odour, serves as a valuable building block and intermediate in chemical synthesis. It is commonly employed in organic chemistry laboratories for various reactions and is a useful reagent for introducing the tert-butoxycarbonyl (Boc) protecting group.
- IUPAC
- Formic acid tert-butylester
- Synonyms
- Formic acid tert-butylestertert-Butyl methanoate
Organic Synthesis Reagent
Tert-Butyl formate is widely used in organic synthesis as a reagent for introducing the tert-butoxycarbonyl (Boc) protecting group onto amines. This protection strategy is fundamental in peptide synthesis and the preparation of complex organic molecules.
Building Block for Fine Chemicals
As a versatile C2 to C5 ester, tert-butyl formate functions as a key building block in the synthesis of various fine chemicals and pharmaceutical intermediates. Its reactivity allows for diverse transformations in multi-step synthetic routes.
Laboratory Research
In academic and industrial research laboratories, tert-butyl formate is utilized for its properties as a carbonyl compound and ester. It facilitates the development of new synthetic methodologies and the exploration of novel chemical entities.
| Molecular weight | 102.13 |
|---|---|
| Linear formula | HCOOC(CH3)3 |
| Assay | ≥98.5% (GC) |
| Boiling point | 82-83 °C(lit.) |
| Density | 0.872 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.379(lit.)n20/D 1.380 |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -9 °C / 15.8 °F |
| Transport (UN / ADR) | UN 3272 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37 |
| Safety statements (S) | 9-16-24-33 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tert-Butyl formate used for?
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Tert-Butyl formate is primarily used as a reagent in organic synthesis for introducing the tert-butoxycarbonyl (Boc) protecting group, acting as a building block for fine chemicals and in laboratory research.
What is the CAS number and formula for tert-Butyl formate?
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The CAS number for tert-Butyl formate is 762-75-4, and its linear formula is HCOOC(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies tert-Butyl formate with a purity of ≥98.5% (GC). This is a technical grade suitable for research and synthesis; TSS does not represent it as USP, BP, or EP grade.
How should tert-Butyl formate be handled safely?
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Tert-Butyl formate is a highly flammable liquid and vapour (H225) and can cause serious eye irritation (H319) and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and use in a well-ventilated area away from ignition sources.
How is tert-Butyl formate packed and exported?
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Tert-Butyl formate is shipped internationally by Tech Serve Solutions in compliance with transport regulations (UN 3272, Class 3, PGII), ensuring safe handling and export.
How can I request a sample or quote for tert-Butyl formate?
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To request a sample or obtain a quote for tert-Butyl formate, please contact our sales department via the website or direct phone line.
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