Terfenadine

CAS 50679-08-8C32H41NO2Biochemicals & Reagents

Terfenadine (CAS: 50679-08-8) is a chemical compound with the molecular formula C32H41NO2 and a molecular weight of 471.67 g/mol. It functions as a selective histamine H1 receptor antagonist. Historically used as an antihistamine, it has found utility in research settings for studying histamine-related pathways, including its role in pruritus associated with proteinase-activated receptors and in the pathogenesis of experimental colitis. Available from Tech Serve Solutions.

IUPAC: α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

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Terfenadine (C32H41NO2) — chemical structure, CAS 50679-08-8; Life Science, fine chemical supplied by Tech Serve Solutions

Application IndexBioactive Small MoleculesBiochemicals and ReagentsCell BiologyCell Signaling EnzymesEnzymesInhibitorsand SubstratesSanofi AventisSubstrates

01 /Applications

Histamine Receptor Research

Terfenadine serves as a valuable tool in research to investigate the function of histamine H1 receptors. It can be used to block these receptors to study their involvement in various physiological and pathological processes.

Pruritus and Itch Studies

This compound has been employed in experimental models to explore the mechanisms of itch and pruritus. Its ability to antagonise histamine receptors aids in understanding the contribution of histamine to sensation in conditions involving proteinase-activated receptors (PARs).

Inflammatory Bowel Disease Models

Terfenadine has been utilised in animal models to investigate the pathogenesis of inflammatory conditions, such as ulcerative colitis. By blocking histamine receptors, researchers can assess the role of histamine signalling in the inflammatory response.

02 /Properties

Molecular weight	471.67
Empirical formula	C32H41NO2
Solubility	chloroform: soluble250 mg plus 5 ml of solvent, clear to very slightly hazy, colorless to faintly yellowH2O: soluble0.01 mg/mL at 30 °C1 M HCl: soluble0.12 mg/mL at 30 °Chexane: soluble0.34 mg/mL at 30 °C0.1 M tartaric acid: soluble0.45 mg/mL0.1 M citric acid: soluble1.1 mg/mLmethanol: soluble37.5 mg/mL at 30 °Cethanol: soluble in salt form37.8 mg/mL at 30 °C
Storage temperature	2-8°C
Application	Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice1. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats2.

03 /Safety & handling

Hazard statements

H413May cause long-lasting harmful effects to aquatic life

Water hazard class (WGK, DE)	2

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

50679-08-8

MDL number

MFCD00079622

PubChem substance

24277779

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Terfenadine used for in research?

Terfenadine is used in research to block histamine receptor type 1 (H1R), aiding the study of histamine's role in itch related to proteinase-activated receptors (PARs) and in the pathogenesis of experimental ulcerative colitis.

What is the CAS number and chemical formula for Terfenadine?

The CAS number for Terfenadine is 50679-08-8, and its chemical formula is C32H41NO2.

What grade and purity does Tech Serve Solutions supply for Terfenadine?

Tech Serve Solutions supplies Terfenadine. The specific grade and purity are available upon request, and TSS does not represent this product as USP, BP, EP, or any other pharmacopoeial grade unless explicitly stated in the product documentation.

What are the safety and handling considerations for Terfenadine?

Terfenadine carries the hazard statement H413, indicating it may cause long lasting harmful effects to aquatic life. It is classified under WGK Germany as 2. Appropriate personal protective equipment should be used, and it should be handled in a well-ventilated area, avoiding release into the environment.

How is Terfenadine packed, shipped, and exported by TSS?

Terfenadine is typically stored at 2-8°C. Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging and documentation for the safe and compliant international shipment of chemicals like Terfenadine.

How can I request a sample or quote for Terfenadine?

To request a sample or a quote for Terfenadine, please contact the Tech Serve Solutions sales team through our website or by calling our office. Please reference the product name and CAS number (50679-08-8).