Tamoxifen

CAS 10540-29-1C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2Biochemicals & Reagents

Tamoxifen (CAS: 10540-29-1) is a synthetic triphenylethylene derivative with the molecular formula C26H29NO and a molecular weight of 371.51 g/mol. This compound is primarily recognised for its antineoplastic properties and is utilised in various research applications, including studies on gene recombination and microglial activation. Available from Tech Serve Solutions, it serves as a crucial reagent in biochemical and cancer research.

IUPAC: (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene,trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
Synonyms: (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butenetrans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine

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Tamoxifen (C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2) — chemical structure, CAS 10540-29-1; Life Science, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Research on Gene Recombination

Tamoxifen has been employed in scientific research to facilitate the recombination of specific genetic alleles, such as the ect2flox allele, within mouse organs. This application is vital for studying gene function and developmental processes.

Study of Microglial Activation

The compound has been utilised in experimental settings to investigate its effects on lipopolysaccharide (LPS)-induced microglial activation. This research contributes to understanding neuroinflammatory responses.

Antitumor Research

As an antineoplastic agent, Tamoxifen is a subject of interest in cancer research, exploring its mechanisms and potential applications in developing therapeutic strategies.

02 /Properties

Molecular weight	371.51
Linear formula	C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2
Assay	≥99%
Solubility	H2O: insoluble chloroform: soluble50 mg/mL, clear, colorless to faintly yellow2-propanol: solubleDMSO: solubleethanol: solublemethanol: solublepropylene glycol: soluble
Storage temperature	2-8°C
Application	Tamoxifen has been used to facilitate the recombination of ect2flox allele in mouse organs91. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation92.
Melting point	97-98 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H350May cause cancer
H360May damage fertility or the unborn child
H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use
P263
P308IF exposed or concerned

Protective equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	45-60-61-64
Safety statements (S)	53-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

10540-29-1

MDL number

MFCD00010454

PubChem substance

24900307

05 /Additional specifications

Gene Information	human ... CYP1A2(1544), EBP(10682), ESR1(2099), ESR2(2100), ESRRA(2101)rat ... Ar(24208), Esr1(24890)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Tamoxifen used for?

Tamoxifen is used in research applications, including facilitating gene recombination in mouse organs and studying its effects on microglial activation. It is also recognised for its antineoplastic properties and is of interest in antitumor research.

What are the CAS number and chemical formula for Tamoxifen?

The CAS number for Tamoxifen is 10540-29-1, and its linear chemical formula is C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tamoxifen with an assay of ≥99%. We do not represent this product as USP, BP, or EP grade.

How should Tamoxifen be handled and stored?

Tamoxifen carries significant health hazards, indicated by GHS08 symbol and 'Danger' signal word, with hazard statements H350 (May cause cancer), H360 (May damage fertility or the unborn child), and H362 (May cause harm to breast-fed children). It requires strict personal protective equipment, including eyeshields, appropriate respirators, and gloves. Store at 2-8°C.

Is Tamoxifen a controlled substance?

The provided data indicates hazard codes and statements related to carcinogenicity, mutagenicity, and reproductive toxicity, but does not specify controlled substance scheduling. Users are advised to consult local regulations.

How is Tamoxifen packed and exported?

Tech Serve Solutions specialises in the global supply and export of fine chemicals. Specific packaging and export details for Tamoxifen will be provided upon inquiry.

How can I request a sample or quote for Tamoxifen?

To request a sample or quote for Tamoxifen, please contact our sales department through the website or by phone, referencing the product CAS number 10540-29-1.