T-2 Toxin
T-2 Toxin (CAS: 21259-20-1; C24H34O9; MW: 466.52) is a potent mycotoxin produced by Fusarium species. Characterised as a white powder, it is known for its significant cytotoxicity and immunotoxicity. T-2 toxin is primarily utilised in research settings to study cellular stress responses, apoptosis, and the mechanisms of oxidative damage, particularly within cell biology and neuroscience research.
- IUPAC
- 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate,4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
Cellular Stress Research
T-2 toxin is employed in studies investigating the mechanisms of cellular stress, including oxidative stress and apoptosis. Its ability to induce cell death in various cell types makes it a valuable tool for understanding stress signalling pathways.
Immunotoxicity Studies
Research utilises T-2 toxin to examine its effects on the immune system. Studies have shown it can cause cell death in human lymphoid T cells and damage B cell membranes, contributing to the understanding of immunomodulatory effects.
Cartilage Degeneration Studies
In animal models, T-2 toxin has been observed to cause degenerative lesions in articular cartilage. This application is relevant for research into joint health and the pathological processes of cartilage breakdown.
Neuroscience Research
Given its impact on cell signalling, T-2 toxin can be used in neuroscience research to investigate its effects on neuronal cells and their functions, particularly in contexts involving cell stress and potential neurotoxicity.
| Molecular weight | 466.52 |
|---|---|
| Empirical formula | C24H34O9 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white |
| Solubility | chloroform: soluble9.80 - 10.20 mg/mL, clear, colorless to faintly yellowDMSO: freely solublepetroleum ether: slightly soluble |
| Storage temperature | −20°C |
| Application | T-2 toxin can cause degenerative lesions in articular cartilage of rats8. Furthermore, immunotoxicity studies have reported that T-2 toxin can cause cell death in human lymphoid T cells and also induces cell membrane damage in B cells9. |
| Biological source | from Fusarium sp. |
Hazard statements
- H300Fatal if swallowed
- H315Causes skin irritation
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28-38 |
| Safety statements (S) | 22-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Availability | not available in Japannot available in USA |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is T-2 Toxin used for?
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T-2 Toxin is used in scientific research for studying cellular stress, apoptosis, immunotoxicity, and cartilage degeneration. It is a tool for investigating cellular responses to mycotoxins and oxidative damage.
What are the CAS number and formula for T-2 Toxin?
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The CAS number for T-2 Toxin is 21259-20-1, and its empirical formula is C24H34O9.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies T-2 Toxin with an assay of ≥98% as determined by HPLC. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should T-2 Toxin be handled safely?
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T-2 Toxin is a highly toxic substance requiring extreme caution. Handle with appropriate personal protective equipment, including eyeshields, faceshields, gloves, and a full-face particle respirator (NIOSH N100 or equivalent). Ensure adequate ventilation and avoid inhalation, ingestion, and skin contact. Refer to the Safety Data Sheet for detailed handling procedures.
Is T-2 Toxin a controlled substance?
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While the provided data does not explicitly state T-2 Toxin is a controlled substance in all jurisdictions, its high toxicity (indicated by GHS06 Danger signal word and H300+H310+H330 hazard statements) necessitates strict handling and regulatory compliance. Please verify local regulations.
How is T-2 Toxin packed and shipped?
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T-2 Toxin is supplied as a white powder. Specific packaging and shipping details are available upon request, adhering to all relevant transport regulations for hazardous materials.
How can I request a quote or sample for T-2 Toxin?
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To request a quote or a sample of T-2 Toxin, please contact the Tech Serve Solutions sales team through our website or direct contact information.
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