SU 11274
SU 11274 (CAS: 658084-23-2), with the molecular formula C28H30ClN5O4S and a molecular weight of 568.09 g/mol, is an orange powder. This compound is primarily utilised as a selective inhibitor of c-Met, a receptor tyrosine kinase. It has been employed in research settings to investigate the role of c-Met signalling in various cellular processes, particularly in the context of cancer biology.
- IUPAC
- (3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
c-Met Kinase Inhibition
SU 11274 acts as an inhibitor of the c-Met receptor tyrosine kinase. This activity makes it a valuable tool for studying the biological functions and therapeutic potential of targeting the c-Met pathway in cellular models.
Cancer Research
The compound has been used to explore the effects of c-Met inhibition in non-small cell lung cancer cell lines. Its application aids in understanding the mechanisms by which c-Met signalling contributes to tumour growth and progression.
Cell Signaling Studies
As a modulator of receptor tyrosine kinase activity, SU 11274 is useful for investigating complex cell signaling cascades. It helps researchers dissect the downstream effects of c-Met activation or inhibition.
| Molecular weight | 568.09 |
|---|---|
| Empirical formula | C28H30ClN5O4S |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | orange |
| Solubility | DMSO: soluble10 mg/mL at 60 °CH2O: insoluble |
| Storage temperature | 2-8°C |
| Application | SU 11274 was used to inhibit c-Met in non-small cell lung cancer cell lines.3 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SU 11274 used for?
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SU 11274 is used as a selective inhibitor of c-Met, a receptor tyrosine kinase, particularly in cancer research and cell signaling studies. It has been applied to investigate c-Met signalling in non-small cell lung cancer cell lines.
What is the CAS number and molecular formula for SU 11274?
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The CAS number for SU 11274 is 658084-23-2, and its molecular formula is C28H30ClN5O4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies SU 11274 with a purity of ≥98% by HPLC. This product is intended for research and laboratory use. TSS does not represent it as USP, BP, or EP grade.
How should SU 11274 be handled safely?
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SU 11274 is classified with a Warning signal word and carries hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, in a well-ventilated area.
Is SU 11274 a controlled substance?
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The provided data does not indicate that SU 11274 is a controlled substance.
How is SU 11274 packed and shipped?
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SU 11274 is typically supplied as an orange powder and should be stored at 2-8°C. TSS exports fine chemicals globally, adhering to all relevant shipping and customs regulations.
How can I request a sample or quote for SU 11274?
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To request a sample or a quote for SU 11274, please contact the Tech Serve Solutions sales team via our website or direct contact details.
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