Sanguinarine chloride hydrate
Sanguinarine chloride hydrate (CAS: 5578-73-4) is a quaternary benzo[c]phenanthridine alkaloid derived from plants like Macleya cordata. Characterised by its empirical formula C20H14ClNO4 · xH2O and a molecular weight of 367.78 (anhydrous basis), it exhibits solubility in methanol and limited solubility in water. This compound is primarily utilised in research settings, notably for its anti-proliferative and anti-schistosomal activities, and as an inhibitor of lipase.
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Anti-Schistosomal Activity Research
Sanguinarine chloride hydrate has been investigated for its potential anti-schistosomal properties. Studies have explored its efficacy against *Schistosoma mansoni*, a parasitic flatworm that causes schistosomiasis.
Lipase Inhibition Studies
The compound has been evaluated for its anti-lipase activity. Research has included testing its effects on lipases, such as *Candida rugosa* lipase, which are enzymes involved in breaking down fats.
Anti-Proliferative Agent Research
As an anti-proliferative agent, sanguinarine chloride hydrate is studied for its effects on cell growth and division, particularly in the context of cancer research and chemoprevention.
| Molecular weight | 367.78 (anhydrous basis) |
|---|---|
| Empirical formula | C20H14ClNO4 · xH2O |
| Assay | ≥98% (HPLC) |
| Solubility | H2O: slightly soluble methanol: soluble3.8 mg/mL |
| Application | Sanguinarine chloride hydrate was tested for anti-schistosomal activities against Schistosoma mansoni.9 It was tested for anti-lipase activity against Candida rugosa lipase.10 |
| Biological source | (Macleaya cordata and microcarpa) |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sanguinarine chloride hydrate used for?
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Sanguinarine chloride hydrate is primarily used in research for its anti-schistosomal and anti-lipase activities, and as an anti-proliferative agent. It is studied in fields such as cancer research, cell biology, and nutrition research.
What are the CAS number and formula for Sanguinarine chloride hydrate?
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The CAS number for the anhydrous form is 5578-73-4. The empirical formula is C20H14ClNO4 · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Sanguinarine chloride hydrate with a purity of ≥98% (HPLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling precautions for Sanguinarine chloride hydrate?
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Sanguinarine chloride hydrate is classified with GHS07 symbol and a 'Warning' signal word, with hazard statement H302 (Harmful if swallowed). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. WGK Germany classification is 3.
How is Sanguinarine chloride hydrate packed, shipped, and exported?
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Sanguinarine chloride hydrate is carefully packed and securely shipped by Tech Serve Solutions, a global supplier and exporter of fine chemicals, ensuring compliance with international shipping regulations.
How can I request a sample or quote for Sanguinarine chloride hydrate?
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To request a sample or a quote for Sanguinarine chloride hydrate, please contact the Tech Serve Solutions sales team through our website or via direct inquiry.
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