Saclofen

CAS 125464-42-8C9H12ClNO3SBiochemicals & Reagents

Saclofen (CAS: 125464-42-8) is a chemical compound with the empirical formula C9H12ClNO3S and a molecular weight of 249.71 g/mol. Available as a white solid, Saclofen functions as a selective antagonist for GABA-B receptors. This property makes it a valuable tool in neurochemical research, particularly for studying the roles of GABAergic neurotransmission and associated signalling pathways in the central nervous system.

IUPAC: β-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid

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Saclofen (C9H12ClNO3S) — chemical structure, CAS 125464-42-8; Life Science, fine chemical supplied by Tech Serve Solutions

AntagonistsBioactive Small MoleculesBiochemicals and ReagentsCell BiologyGABAergicsGPCR ModulatorsGPCR ProteinsModulators and AntibodiesNeuroscienceNeurotransmission

01 /Applications

GABA-B Receptor Antagonist

Saclofen is a well-established antagonist specifically targeting the GABA-B receptor. It is widely utilised in neuropharmacological research to investigate the physiological and behavioural effects of modulating GABA-B receptor activity.

Neuroscience Research Tool

As a selective blocker of GABA-B receptors, Saclofen is instrumental in studies of neurotransmission. It helps researchers elucidate the complex roles of GABA, the primary inhibitory neurotransmitter, in neuronal function and brain circuitry.

Pharmacological Probe

The compound serves as a precise pharmacological probe for GABBR1 and GABBR2 receptors in various model organisms, including human, mouse, and rat systems. This aids in understanding receptor function and identifying potential therapeutic targets.

02 /Properties

Molecular weight	249.71
Empirical formula	C9H12ClNO3S
Form	solid
Colour	white
Solubility	0.1 M NaOH: soluble20 mg/mL

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

125464-42-8

MDL number

MFCD00216817

05 /Additional specifications

Gene Information	human ... GABBR1(2550), GABBR2(9568)mouse ... GABBR1(54393), GABBR2(242425)rat ... GABBR1(81657), GABBR2(83633)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Saclofen primarily used for?

Saclofen is primarily used as a selective antagonist for GABA-B receptors in neurochemical and pharmacological research. It is a valuable tool for studying neurotransmission, particularly the role of GABAergic pathways in the central nervous system.

What is the CAS number and chemical formula for Saclofen?

The CAS number for Saclofen is 125464-42-8. Its empirical formula is C9H12ClNO3S.

What grade and purity does Tech Serve Solutions supply for Saclofen?

Tech Serve Solutions supplies Saclofen in technical/research grade. We do not represent this product as USP, BP, or EP grade.

What are the safety and handling precautions for Saclofen?

Appropriate personal protective equipment should be used when handling Saclofen, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK Germany 3.