S-Acetamidomethyl-L-cysteine hydrochloride
S-Acetamidomethyl-L-cysteine hydrochloride (CAS: 28798-28-9; C6H12N2O3S · HCl) is a derivative of L-cysteine, a naturally occurring amino acid. This compound features an acetamidomethyl group protecting the thiol functionality. It serves as a valuable building block in peptide synthesis and chemical biology research. Its structure allows for controlled incorporation into peptide chains and subsequent deprotection, facilitating the study of cysteine-containing peptides and proteins.
- IUPAC
- H-Cys(Acm).HCl

Peptide Synthesis
Used as a protected form of cysteine in solid-phase and solution-phase peptide synthesis. The acetamidomethyl group offers stability during coupling reactions and can be selectively removed under specific conditions.
Chemical Biology Research
Employed in studies investigating the role of cysteine residues in protein function and modification. It allows for site-specific labelling or manipulation of cysteine in biomolecules.
Organic Synthesis Intermediate
Serves as a chiral building block for the synthesis of complex organic molecules and pharmaceutical intermediates. Its defined stereochemistry is crucial for targeted synthesis.
| Molecular weight | 228.70 |
|---|---|
| Empirical formula | C6H12N2O3S · HCl |
| Assay | ≥99.0% (AT) |
| Optical activity | [α]20/D −28±2°, c = 1% in H2O |
| Melting point | ~165 °C (dec.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is S-Acetamidomethyl-L-cysteine hydrochloride used for?
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S-Acetamidomethyl-L-cysteine hydrochloride is primarily used in peptide synthesis and chemical biology research as a protected form of cysteine, allowing for controlled incorporation into peptide chains.
What is the CAS number and formula for S-Acetamidomethyl-L-cysteine hydrochloride?
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The CAS number is 28798-28-9 and the empirical formula is C6H12N2O3S · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies S-Acetamidomethyl-L-cysteine hydrochloride with an assay of ≥99.0% (AT). This product is intended for research and technical use and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should S-Acetamidomethyl-L-cysteine hydrochloride be handled?
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Appropriate personal protective equipment should be used, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Handle in a well-ventilated area. Consult the Safety Data Sheet for full details.
What is the melting point of S-Acetamidomethyl-L-cysteine hydrochloride?
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S-Acetamidomethyl-L-cysteine hydrochloride has a melting point of approximately 165 °C with decomposition.
How is this product packed and shipped?
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Tech Serve Solutions offers various packaging options suitable for laboratory reagents and fine chemicals, ensuring safe export and delivery worldwide.
How can I request a quote or sample?
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To request a quote or sample, please visit the Tech Serve Solutions website or contact our sales team directly through the provided contact details.
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