(S)-(+)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane
(S)-(+)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane (CAS: 192463-40-4) is a chiral diphosphine ligand with a molecular weight of 576.65 g/mol. Utilised in asymmetric synthesis, it is particularly effective for the enantioselective hydrogenation of dehydroamino acid derivatives and ketones. Its unique phane-based structure makes it a valuable tool for catalytic processes requiring high stereocontrol, contributing to the efficient synthesis of enantiomerically pure compounds.
- IUPAC
- (S)-Phanephos
- Synonyms
- C40H34P2(S)-Phanephos
![(S)-(+)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane (C40H34P2) — chemical structure, CAS 192463-40-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F192463-40-4.png&w=3840&q=75)
Asymmetric Hydrogenation
Serves as an efficient chiral ligand for the asymmetric hydrogenation of dehydroamino acids and their derivatives, enabling the synthesis of enantiomerically enriched amino acids. It is also effective in the asymmetric hydrogenation of ketones.
Chiral Catalyst Development
As a member of the privileged P-Phos ligand family, it is instrumental in the development of sophisticated chiral catalysts for various stereoselective transformations in organic synthesis.
Pharmaceutical Intermediate Synthesis
Facilitates enantioselective synthesis routes, crucial for the production of chiral pharmaceutical intermediates where specific stereoisomers are required for therapeutic efficacy.
| Molecular weight | 576.65 |
|---|---|
| Empirical formula | C40H34P2 |
| Assay | 96% |
| Optical activity | [α]22/D +34°, c = 1 in chloroform |
| Application | Efficient ligand for asymmetric hydrogentation of dehydroamino acids, methyl esters and keytones.1,2 |
| Melting point | 224-226 °C |
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-(+)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane primarily used for?
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(S)-(+)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane is primarily used as an efficient chiral ligand for the asymmetric hydrogenation of dehydroamino acids and ketones.
What are the CAS number and formula for this compound?
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The CAS number is 192463-40-4, and the molecular formula is C40H34P2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at 96% purity. It is supplied as a research or technical grade chemical and is not represented as USP, BP, EP, or other pharmacopoeial standards.
What are the safety and handling recommendations for this chemical?
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Handling requires a dust mask type N95 (US), eyeshields, and gloves. The compound is classified as an irritant (Xi) with risk statement R37 (Irritating to the respiratory system). Appropriate ventilation and personal protective equipment are essential during handling.
How is this chemical shipped and exported?
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Tech Serve Solutions specialises in the global supply and export of fine chemicals. This compound can be packed and shipped according to international regulations for chemical transport.
How can I request a sample or a quote?
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To request a sample or a quotation for (S)-(+)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane, please contact the Tech Serve Solutions sales team through our website or direct contact details.
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