S-(1-Oxido-2-pyridyl)-N,N,N′,N′-tetramethylthiuronium hexafluorophosphate
S-(1-Oxido-2-pyridyl)-N,N,N′,N′-tetramethylthiuronium hexafluorophosphate (CAS 212333-72-7) is a synthetic reagent with the molecular formula C10H16F6N3OPS and a molecular weight of 371.28 g/mol. This compound serves as a valuable tool in organic synthesis, particularly for coupling reactions and the preparation of various functionalised molecules. It is widely employed in peptide chemistry and the synthesis of inhibitors, chiral building blocks, and amides.
- IUPAC
- N,N,N′,N′-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate,S-(2-Pyridyl)-N,N,N′,N′-tetramethylthiuronium N-oxide hexafluorophosphate
- Synonyms
- N′-tetramethylthiuronium hexafluorophosphate212333-72-7C10H16F6N3OPSN,N,N′,N′-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphateS-(2-Pyridyl)-N,N,N′,N′-tetramethylthiuronium N-oxide hexafluorophosphate
Synthesis of Inhibitors
This reagent is utilised in the synthesis of inhibitors for PAD1, PAD3, and PAD4, contributing to research in biochemical pathways and drug discovery.
Preparation of Chiral Building Blocks
It facilitates the synthesis of enantiomerically pure vinylcyclopropylboronic esters and cyclopropane building blocks, essential for stereoselective synthesis in medicinal chemistry.
Peptide Coupling and Amide Synthesis
The compound is an effective reagent for both solution-phase and solid-phase peptide coupling. It also aids in the conversion of carboxylic acids to Weinreb amides and other N-methoxy or N-benzoxy amides.
Chiral Auxiliary in Radical Chemistry
A camphor-derived chiral auxiliary utilising this reagent has been developed for stereoselective transformations involving hydroxyalkyl radicals.
| Molecular weight | 371.28 |
|---|---|
| Empirical formula | C10H16F6N3OPS |
| Assay | ≥95.0% (NMR) |
| Storage temperature | −20°C |
| Application | Reagent for: Synthesis of inhibitors for PAD1, 3, and 41 Synthesis of enantiomerically pure vinylcyclopropylboronic esters2 Synthesis of enantiomerically pure cyclopropane building blocks3 Camphor-derived chiral auxiliary for hydroxyalkyl radicals4 Solution and solid-phase coupling5 Conversion of carboxylic acids to Weinreb amides and N-methoxy or N-benzoxy amides6 |
| Melting point | 120-125 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is S-(1-Oxido-2-pyridyl)-N,N,N′,N′-tetramethylthiuronium hexafluorophosphate used for?
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It is primarily used as a synthetic reagent in organic chemistry. Applications include the synthesis of inhibitors for PAD1, 3, and 4, preparation of enantiomerically pure vinylcyclopropylboronic esters and cyclopropane building blocks, and in both solution and solid-phase peptide coupling reactions. It also aids in the conversion of carboxylic acids to amides.
What are the CAS number and chemical formula for this product?
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The CAS number is 212333-72-7, and the empirical formula (Hill notation) is C10H16F6N3OPS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥95.0% (NMR). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product data.
How should S-(1-Oxido-2-pyridyl)-N,N,N′,N′-tetramethylthiuronium hexafluorophosphate be handled?
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Safe handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK 2 in Germany, indicating it is hazardous to water.
Is this product available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents.
How can I request a quote or sample?
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Please contact our sales team directly through our website or by calling us to request a quotation or a sample for this product.
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