Ro 41-0960
Ro 41-0960 (CAS: 125628-97-9; Formula: C13H8FNO5) is a yellow solid compound with a molecular weight of 277.20 g/mol. As a potent inhibitor, it plays a significant role in biochemical research, particularly in studies involving Catechol-O-methyltransferase (COMT). Its applications span cell biology and neuroscience, aiding in the investigation of neurotransmission and enzyme activity.
- IUPAC
- 2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
Catechol-O-methyltransferase (COMT) Inhibition
Ro 41-0960 is widely utilised as a selective inhibitor of the enzyme Catechol-O-methyltransferase. This enzyme is critical in the metabolism of catecholamine neurotransmitters, making Ro 41-0960 a valuable tool for studying neurotransmitter pathways and their regulation.
Neuroscience Research
This compound serves as a research chemical for investigating neuronal function and neurotransmission. By inhibiting COMT, it can modulate the levels of dopamine, norepinephrine, and epinephrine, providing insights into neurological processes and disorders.
Cell Signaling Studies
Ro 41-0960 aids in understanding cell signaling cascades that are influenced by catecholamines. Researchers use it to explore the downstream effects of altered neurotransmitter levels in various cellular models.
Enzyme Activity Modulation
As an enzyme inhibitor, Ro 41-0960 is instrumental in biochemical assays designed to study enzyme kinetics and mechanisms of action. It allows for controlled manipulation of COMT activity to observe its effects on biological systems.
| Molecular weight | 277.20 |
|---|---|
| Empirical formula | C13H8FNO5 |
| Form | solid |
| Colour | yellow |
| Solubility | H2O: slightly soluble 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble1.0 mg/mLethanol: soluble |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... COMT(1312) |
|---|---|
| Storage Condition | protect from light |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ro 41-0960 used for?
+
Ro 41-0960 is primarily used as a research chemical for its potent and selective inhibitory activity against Catechol-O-methyltransferase (COMT). It is employed in neuroscience, cell biology, and enzyme inhibition studies to investigate neurotransmission and neurotransmitter metabolism.
What are the CAS number and formula for Ro 41-0960?
+
The CAS number for Ro 41-0960 is 125628-97-9, and its molecular formula is C13H8FNO5.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Ro 41-0960 as a research-grade chemical. The specific purity is available on the Certificate of Analysis for each batch. We do not represent this product as USP, BP, EP, or pharmaceutical grade.
How should Ro 41-0960 be handled and stored?
+
Ro 41-0960 should be handled with appropriate personal protective equipment, including eyeshields and gloves, and with a suitable respirator. It is sensitive to light and should be stored under refrigeration (2-8°C) and protected from light.
How is Ro 41-0960 shipped and exported?
+
Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Ro 41-0960 is packed securely and shipped in compliance with international regulations for chemical transport. We handle all export documentation.
How can I request a sample or quote for Ro 41-0960?
+
To request a sample or a quotation for Ro 41-0960, please contact our sales team through the website or by phone. Please specify the quantity required and your delivery location.
▶ Related products
(−)-Curcumol
C15H24O2
Cell Biology
(±) Clopidogrel hydrogensulfate
Cell Biology
(±)-L-Alliin
C6H11NO3S
Cell Biology
(±)-2-Amino-4-phosphonobutyric acid
C4H10NO5P
Cell Biology
(±)-2-Methylarachidonoyl-2′-fluoroethylamide
C23H38NOF
Cell Biology
(±)-3,4-Methylenedioxy-N-ethylamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxyamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxymethamphetamine hydrochloride
Cell Biology
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis