(R)-(+)-Warfarin
(R)-(+)-Warfarin (CAS: 5543-58-8), a chiral coumarin derivative with the molecular formula C19H16O4 and a molecular weight of 308.33 g/mol, is a critical research chemical. It is commonly employed in studies investigating drug metabolism, particularly in the upregulation of hepatic CYP3A4 and CYP2C enzymes. This compound has also been utilised in cell-based assays, such as in HepG2 cells, for proteomic analysis, aiding advancements in cellular biology and signaling pathways.
- IUPAC
- R-(+)-3-Acetonybenzyl)-4-hydroxycoumarin,R-(+)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
- Synonyms
- R-(+)-3-Acetonybenzyl)-4-hydroxycoumarinR-(+)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
Drug Metabolism Studies
Utilised to investigate the mechanisms of drug metabolism, particularly its role in upregulating hepatic CYP3A4 and CYP2C enzymes in biological systems.
Cellular Proteomics
Applied in cell culture, for instance with HepG2 cells, to facilitate proteomic analyses and understand cellular protein profiles under specific experimental conditions.
Enzyme Activity Research
Serves as a valuable tool for researchers studying the induction and activity of cytochrome P450 enzymes, providing insights into xenobiotic metabolism.
| Molecular weight | 308.33 |
|---|---|
| Empirical formula | C19H16O4 |
| Assay | ≥97% (HPLC) |
| Colour | white to pale yellow |
| Solubility | DMF: solubleDMSO: solubleethanol: soluble |
| Storage temperature | 2-8°C |
| Application | Studies using (R)-(+)-warfarin have reported that it can upregulate hepatic CYP3A4 and CYP2C1. It has also been used in HepG2 cells to study protein profiles2. |
| Melting point | ≥170 °C |
Hazard statements
- H360D
- H372Causes damage to organs through prolonged exposure
- H412Harmful to aquatic life with long-lasting effects
Precautionary statements
- P201Obtain special instructions before use
- P273Avoid release to the environment
- P308IF exposed or concerned
| Transport (UN / ADR) | UN 2811 6.1 / PGI |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 61-48/25-52/53 |
| Safety statements (S) | 53-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CYP2C9(1559) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-Warfarin used for?
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(R)-(+)-Warfarin is primarily used in research for studying drug metabolism, particularly its effects on hepatic CYP enzymes like CYP3A4 and CYP2C, and in cell-based proteomic analyses.
What are the CAS number and molecular formula for (R)-(+)-Warfarin?
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The CAS number for (R)-(+)-Warfarin is 5543-58-8, and its molecular formula is C19H16O4.
What grade and purity does Tech Serve Solutions supply for (R)-(+)-Warfarin?
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Tech Serve Solutions supplies (R)-(+)-Warfarin with a purity of ≥97% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should (R)-(+)-Warfarin be handled and stored?
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(R)-(+)-Warfarin is classified as Danger, with hazards including potential reproductive toxicity and organ damage through prolonged or repeated exposure, and is harmful to aquatic life with long-lasting effects. It requires careful handling and storage at 2-8°C, in accordance with its hazard statements (H360D-H372-H412).
Is (R)-(+)-Warfarin a controlled substance?
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Based on the provided data, (R)-(+)-Warfarin is classified under UN 2811, Hazard Class 6.1, Packing Group I, indicating it is a toxic solid for transport, but it is not explicitly listed as a controlled substance in this context.
How can I request a quote or sample for (R)-(+)-Warfarin?
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To request a quote or a sample of (R)-(+)-Warfarin, please contact our sales team through the TSS website or by phone.
Is (R)-(+)-Warfarin available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals like (R)-(+)-Warfarin.
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